{"id":"W2122718122","doi":"10.1002/ijc.27710","title":"Silencing IDO in dendritic cells: A novel approach to enhance cancer immunotherapy in a murine breast cancer model","year":2012,"lang":"en","type":"article","venue":"International Journal of Cancer","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":101,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lawson Health Research Institute; Western University","funders":"Canadian Institutes of Health Research; Cure Brain Cancer Foundation; Lawson Health Research Institute","keywords":"Immunotherapy; Gene silencing; Medicine; FOXP3; Cancer research; Dendritic cell; Cancer; Cancer immunotherapy; Antigen; Breast cancer; Immunology; CD8; CTL*; Cancer vaccine; Immune system; Biology; Internal medicine; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001931916,0.0004030544,0.0003594281,0.0003086898,0.0001541416,0.000322007,0.0002487957,0.0004976611,0.0007156559],"category_scores_gemma":[0.00006160811,0.0001399206,0.0002648611,0.0001478748,0.0002751581,0.0002143739,0.0001599278,0.0009093158,0.0003252749],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003389425,"about_ca_system_score_gemma":0.0004103356,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004536919,"about_ca_topic_score_gemma":0.0006373595,"domain_scores_codex":[0.9998323,0.00002240906,0.0000129621,0.00004175225,0.00005237414,0.00003820834],"domain_scores_gemma":[0.9999342,0.000007652803,0.00001741412,0.0000105605,0.000009554981,0.00002066521],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007103863,0.00005569058,0.00005484527,0.00002925907,0.000002597326,0.00001638621,0.00000873483,0.00005728248,0.9985215,0.0001224473,0.00003935751,0.001020777],"study_design_scores_gemma":[0.00002835131,0.0003055244,0.0003545179,0.000003460787,0.0000134616,0.00007357993,0.000006329676,0.0006779192,0.9958214,0.00003493858,0.002678249,0.000002282348],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9684295,0.003286887,0.02177051,0.0006807253,0.0002315413,0.0002340286,0.0007868073,0.0003290153,0.004250965],"genre_scores_gemma":[0.9726351,0.002875275,0.01627304,0.0002198017,0.00005018197,0.0002396469,0.0006141309,0.00006313039,0.007029804],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007156559,"threshold_uncertainty_score":0.002459228,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02571100048573888,"score_gpt":0.3351746584434451,"score_spread":0.3094636579577063,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}