{"id":"W2122729818","doi":"10.1016/j.jconrel.2013.01.002","title":"A hydrogel composite system for sustained epi-cortical delivery of Cyclosporin A to the brain for treatment of stroke","year":2013,"lang":"en","type":"article","venue":"Journal of Controlled Release","topic":"Nerve injury and regeneration","field":"Neuroscience","cited_by":81,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Stroke (engine); Cortical neurons; Composite number; Chemistry; Biomedical engineering; Pharmacology; Medicine; Neuroscience; Materials science; Psychology; Composite material","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004197085,0.0001345374,0.0006664604,0.0001264287,0.0001211783,0.000025072,0.0001802801,0.00005556763,0.000005291661],"category_scores_gemma":[0.0006666163,0.00007144545,0.0005600156,0.00009817766,0.00005218379,0.0001075419,0.0000116009,0.00005423494,0.000001765453],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008986793,"about_ca_system_score_gemma":0.0001407885,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001540989,"about_ca_topic_score_gemma":0.000003816932,"domain_scores_codex":[0.998315,0.0001956124,0.0008950861,0.0001322017,0.0002611814,0.00020087],"domain_scores_gemma":[0.99687,0.001627535,0.000718233,0.0001734737,0.000465495,0.0001451936],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01212187,0.0004450337,0.00004004359,0.00007716939,0.000119754,0.00001260506,0.0001521885,0.001840853,0.9787708,0.00260649,0.0004976765,0.003315549],"study_design_scores_gemma":[0.02717919,0.005663434,0.00009211351,0.00009443216,0.0003403178,0.00006756142,0.0003436748,0.03504783,0.9301032,0.0002223286,0.0007361265,0.0001097717],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9848571,0.0002351187,0.00845805,0.003612664,0.0002550058,0.002477264,0.00006357191,0.000006197983,0.0000350142],"genre_scores_gemma":[0.9982266,0.00001930081,0.0005854741,0.0001910695,0.000262649,0.0001584484,9.470063e-7,0.00001290907,0.0005425594],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04866754,"threshold_uncertainty_score":0.2913461,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01531700346506056,"score_gpt":0.2630049234603953,"score_spread":0.2476879199953347,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}