{"id":"W2122773858","doi":"10.1091/mbc.e09-08-0699","title":"Synthetic Lethal Genetic Interactions That Decrease Somatic Cell Proliferation in Caenorhabditis elegans Identify the Alternative RFC<sup>CTF18</sup>as a Candidate Cancer Drug Target","year":2009,"lang":"en","type":"article","venue":"Molecular Biology of the Cell","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Biology; Caenorhabditis elegans; Synthetic lethality; Somatic cell; Gene; Genetic screen; RNA interference; Genetics; Gene knockdown; Phenotype; Lethal allele; Mutation; Model organism; DNA repair; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001195474,0.0005778543,0.0001862817,0.0003641612,0.000151167,0.0001943232,0.0002538595,0.0002373237,0.001423301],"category_scores_gemma":[0.0001083702,0.000144116,0.000169201,0.0001216102,0.0002477315,0.0001074413,0.0001907561,0.0003548635,0.0002549522],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005753497,"about_ca_system_score_gemma":0.0002615656,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00159994,"about_ca_topic_score_gemma":0.00426292,"domain_scores_codex":[0.9998399,0.00001735546,0.00001623905,0.00003678422,0.00006267701,0.00002704831],"domain_scores_gemma":[0.9998596,0.00002565354,0.00005781843,0.00001238818,0.00001281784,0.00003162685],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003100565,0.00001374012,0.0001867269,0.00001687706,0.000003195781,0.00002809134,0.000001933502,0.00008992607,0.9988696,0.00005726711,0.00003036051,0.0006713115],"study_design_scores_gemma":[0.00001106767,0.0001057169,0.002834802,0.000004598808,0.000008101899,0.0001179063,0.000006046489,0.0009086964,0.9943451,0.00001756478,0.001637512,0.000003001608],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910795,0.001094773,0.004455965,0.00008516484,0.00002313309,0.00006578016,0.0009522944,0.0002087294,0.002034537],"genre_scores_gemma":[0.9869499,0.0006049421,0.008588968,0.00005611544,0.000004935722,0.00008508395,0.0007705785,0.00005516259,0.002884279],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00159994,"threshold_uncertainty_score":0.004761398,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005733445520493351,"score_gpt":0.2528833424590994,"score_spread":0.2471498969386061,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}