{"id":"W2122778067","doi":"10.1128/aac.44.10.2816-2823.2000","title":"Safety, Tolerability, and Pharmacokinetics of Single Oral Doses of BCH-10652 in Healthy Adult Males","year":2000,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"BioPhage Pharma (Canada)","funders":"","keywords":"Pharmacokinetics; Chemistry; Tolerability; Pharmacology; Liter; Volume of distribution; Placebo; Oral administration; Internal medicine; Adverse effect; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000284895,0.0002528008,0.0005109084,0.0001142467,0.000170705,0.0001658552,0.00009048578,0.0003133242,0.001175173],"category_scores_gemma":[0.0005136984,0.00015616,0.0002187143,0.0001074137,0.0001690575,0.0001492384,0.00007055484,0.0003076301,0.0002969653],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001278024,"about_ca_system_score_gemma":0.0001291981,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00064446,"about_ca_topic_score_gemma":0.0009678367,"domain_scores_codex":[0.9998263,0.00006876825,0.0000101093,0.00003916884,0.00003909964,0.00001665284],"domain_scores_gemma":[0.9997264,0.00006307274,0.0001042537,0.00002080168,0.00002587261,0.00005960302],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.175658,0.01020915,0.121279,0.0003686339,0.0005551358,0.0007487754,0.0005992242,0.001328647,0.5081345,0.00009622525,0.001002154,0.1800205],"study_design_scores_gemma":[0.006472101,0.3263148,0.6147481,0.00002355059,0.0005189398,0.00161494,0.0002081304,0.00244267,0.04537548,0.00005370126,0.002191729,0.00003589522],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991615,0.000364892,0.00012713,0.00001598711,0.000003370645,0.00002717161,0.00009627525,0.00001037687,0.0001932791],"genre_scores_gemma":[0.9989309,0.0002168357,0.0002177641,0.00005788169,0.00001951035,0.00002622735,0.0001695707,0.000003541746,0.0003576936],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001175173,"threshold_uncertainty_score":0.003931344,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01649312291918261,"score_gpt":0.2818806240974776,"score_spread":0.265387501178295,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}