{"id":"W2122791003","doi":"10.1038/ncomms6820","title":"Slow unloading leads to DNA-bound β2-sliding clamp accumulation in live Escherichia coli cells","year":2014,"lang":"en","type":"article","venue":"Nature Communications","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":80,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Technische Universiteit Delft; Wellcome Trust","keywords":"Processivity; DNA clamp; DNA replication; Biophysics; Cell biology; Clamp; Fluorescence microscope; Biology; DNA; DNA polymerase; Polymerase; Homologous recombination; Escherichia coli; Chemistry; Fluorescence; Biochemistry; Gene; Polymerase chain reaction; Reverse transcriptase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004437889,0.0001537041,0.0001462568,0.0001001093,0.0001934045,0.00006604382,0.0008447533,0.0004356712,0.00001089574],"category_scores_gemma":[0.0003702718,0.0001728301,0.00006858966,0.0002893511,0.00003594063,0.00001307862,0.0004773967,0.0004855119,0.00005687173],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006547028,"about_ca_system_score_gemma":0.00005366094,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002121932,"about_ca_topic_score_gemma":0.0007389111,"domain_scores_codex":[0.9988739,0.000235873,0.0002338536,0.0002975104,0.0001241137,0.0002347733],"domain_scores_gemma":[0.9980518,0.00009874263,0.00009334007,0.00154972,0.0001190478,0.00008740937],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001414556,0.00005880826,0.001142459,0.000006386291,0.00001079822,1.948582e-7,0.0001992692,0.0002252768,0.9930872,0.003706057,0.001012043,0.000537339],"study_design_scores_gemma":[0.0005353011,0.0001632361,0.006210166,0.00005675538,0.00002775253,0.000002504314,0.0002357623,0.004716131,0.8886687,0.0004803476,0.09846275,0.0004406261],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924123,0.0006803344,0.001930447,0.0009671845,0.0002326064,0.000358561,0.000008200966,0.00004424512,0.003366068],"genre_scores_gemma":[0.9783884,0.00009027784,0.01979528,0.001023645,0.00009542695,0.00006102587,0.0001753125,0.00003037882,0.0003402888],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1044186,"threshold_uncertainty_score":0.7047807,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02285445761373537,"score_gpt":0.3085753124135647,"score_spread":0.2857208547998293,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}