{"id":"W2122816851","doi":"10.1084/jem.20101470","title":"Hexokinase 2 is a key mediator of aerobic glycolysis and promotes tumor growth in human glioblastoma multiforme","year":2011,"lang":"en","type":"article","venue":"The Journal of Experimental Medicine","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":798,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; SickKids Foundation; Toronto Western Hospital; Princess Margaret Cancer Centre; Hospital for Sick Children; Ontario Institute for Cancer Research","funders":"Canadian Institutes of Health Research; American Brain Tumor Association","keywords":"Warburg effect; Anaerobic glycolysis; Hexokinase; Glycolysis; Cancer research; Biology; PKM2; Glioma; Protein kinase B; Temozolomide; Glucose uptake; Pyruvate kinase; Cell growth; Angiogenesis; Cell biology; Endocrinology; Phosphorylation; Metabolism; Biochemistry; Insulin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006096576,0.0002493442,0.0001483587,0.0001880718,0.0001271567,0.0001985286,0.00006398204,0.0001011699,0.0009228007],"category_scores_gemma":[0.00005676824,0.00008049273,0.00009715004,0.0002717377,0.0001069612,0.0001083992,0.0001507583,0.0001938723,0.0001927427],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003279049,"about_ca_system_score_gemma":0.0002467732,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00193377,"about_ca_topic_score_gemma":0.002552909,"domain_scores_codex":[0.9999607,0.000005085541,0.000002591121,0.000007290449,0.0000113061,0.00001296971],"domain_scores_gemma":[0.9999781,0.000001149853,0.000007432215,0.000001367658,0.000003296462,0.000008670753],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000708625,0.00005512186,0.005732254,0.0001571543,0.00002375569,0.0002276358,0.00003426533,0.0002752626,0.9819473,0.0003860432,0.0008318312,0.009620669],"study_design_scores_gemma":[0.0001027914,0.0009824065,0.2096573,0.00002713119,0.00006502392,0.001892407,0.0001450652,0.001719776,0.7599929,0.0007200749,0.0246759,0.00001918951],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9843771,0.009817856,0.001727203,0.0003677222,0.00007119052,0.00002974323,0.00102136,0.00009931956,0.002488306],"genre_scores_gemma":[0.9933535,0.002722356,0.0006363196,0.00006808472,0.00001248688,0.00001522706,0.001075457,0.000005929205,0.002110789],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00193377,"threshold_uncertainty_score":0.003844976,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01301168341524444,"score_gpt":0.2617242055730432,"score_spread":0.2487125221577988,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}