{"id":"W2122847477","doi":"10.1126/scitranslmed.3003824","title":"A Translational Paradigm for the Preclinical Evaluation of the Stroke Neuroprotectant Tat-NR2B9c in Gyrencephalic Nonhuman Primates","year":2012,"lang":"en","type":"article","venue":"Science Translational Medicine","topic":"Acute Ischemic Stroke Management","field":"Medicine","cited_by":108,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Toronto Western Hospital","funders":"","keywords":"Neuroprotection; Medicine; Clinical trial; Stroke (engine); Placebo; Preclinical research; Neuroscience; Magnetic resonance imaging; Diffusion MRI; Physical medicine and rehabilitation; Psychology; Pharmacology; Internal medicine; Pathology; Radiology; Medical physics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006193751,0.0001521941,0.000254944,0.0001822572,0.0002034799,0.00000781803,0.0003966045,0.00004239381,0.0002284969],"category_scores_gemma":[0.0009159888,0.00008051944,0.0001056234,0.0007786368,0.001456977,0.0002330027,0.00002271158,0.0002229831,0.000002465907],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006766399,"about_ca_system_score_gemma":0.0004846745,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002832916,"about_ca_topic_score_gemma":0.00002034586,"domain_scores_codex":[0.9962377,0.000100679,0.0006240902,0.0002989798,0.002368378,0.0003702028],"domain_scores_gemma":[0.9982923,0.000782448,0.0001839554,0.0003593211,0.0002792268,0.0001027901],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001546232,0.001439393,0.5496125,0.0005491831,0.0003200377,0.000001755181,0.01748542,0.006915037,0.2234629,0.06285422,0.001758132,0.1340553],"study_design_scores_gemma":[0.004096336,0.0001767492,0.9300882,0.0001788133,0.0004454652,0.00001884081,0.0002176584,0.0579802,0.002760011,0.001676893,0.002253955,0.0001069351],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8699058,0.00428503,0.01544305,0.09364371,0.001307999,0.007650555,0.0000735962,0.00004162409,0.007648593],"genre_scores_gemma":[0.997589,0.00001905656,0.001293181,0.0004431575,0.0003333768,0.0002289806,0.00001483395,0.00001100271,0.00006741215],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3804757,"threshold_uncertainty_score":0.5368292,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1085399510049123,"score_gpt":0.3970067893202673,"score_spread":0.288466838315355,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}