{"id":"W2122847477","doi":"10.1126/scitranslmed.3003824","title":"A Translational Paradigm for the Preclinical Evaluation of the Stroke Neuroprotectant Tat-NR2B9c in Gyrencephalic Nonhuman Primates","year":2012,"lang":"en","type":"article","venue":"Science Translational Medicine","topic":"Acute Ischemic Stroke Management","field":"Medicine","cited_by":108,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Toronto Western Hospital","funders":"","keywords":"Neuroprotection; Medicine; Clinical trial; Stroke (engine); Placebo; Preclinical research; Neuroscience; Magnetic resonance imaging; Diffusion MRI; Physical medicine and rehabilitation; Psychology; Pharmacology; Internal medicine; Pathology; Radiology; Medical physics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.008336642,0.001798013,0.001261557,0.001211508,0.001811416,0.001469041,0.001198306,0.001654504,0.005572003],"category_scores_gemma":[0.002324578,0.0007446854,0.0008861336,0.0005237777,0.002555749,0.00141391,0.0009395065,0.004274195,0.001169418],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001019523,"about_ca_system_score_gemma":0.00237307,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001235427,"about_ca_topic_score_gemma":0.003159765,"domain_scores_codex":[0.9978378,0.001338714,0.0001966359,0.0002442434,0.0002366444,0.00014596],"domain_scores_gemma":[0.9985747,0.0003046905,0.0002517004,0.000423175,0.0002276254,0.0002181915],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.009038339,0.005265322,0.0008736023,0.001261215,0.0001245391,0.0006320043,0.0006488028,0.0009432138,0.9478502,0.01281565,0.00284363,0.01770349],"study_design_scores_gemma":[0.01034387,0.1425217,0.005603905,0.0009548622,0.0007423505,0.004023397,0.0009654483,0.003717282,0.7382103,0.01411024,0.07860416,0.00020242],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.685579,0.01155631,0.2306365,0.0111165,0.004017022,0.02909598,0.004027521,0.001464519,0.02250675],"genre_scores_gemma":[0.6602668,0.01226754,0.2514631,0.004028562,0.0008924548,0.05727649,0.002519894,0.0003209874,0.01096403],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008336642,"threshold_uncertainty_score":0.04408896,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1085399510049123,"score_gpt":0.3970067893202673,"score_spread":0.288466838315355,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}