{"id":"W2122864632","doi":"10.1074/jbc.m409699200","title":"NARC-1/PCSK9 and Its Natural Mutants","year":2004,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":625,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Montréal; Montreal Clinical Research Institute","funders":"National Heart, Lung, and Blood Institute; National Institutes of Health","keywords":"PCSK9; LDL receptor; Missense mutation; Mutant; Biology; Chemistry; Endocrinology; Lipoprotein; Molecular biology; Internal medicine; Mutation; Cholesterol; Biochemistry; Gene; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008054409,0.0003776179,0.0001742032,0.0002194483,0.0001601466,0.0001696181,0.000329997,0.0002729573,0.001178285],"category_scores_gemma":[0.0001243326,0.0001082977,0.000246196,0.0001727929,0.0002179343,0.00007573232,0.0001625878,0.0004216869,0.0006773766],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004128306,"about_ca_system_score_gemma":0.0002596039,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001036612,"about_ca_topic_score_gemma":0.001146434,"domain_scores_codex":[0.9998813,0.00001424061,0.00001786384,0.00002751688,0.00004129807,0.0000178877],"domain_scores_gemma":[0.9998776,0.00001284377,0.00004641439,0.00001489383,0.00001199492,0.00003627216],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002252241,0.00003976591,0.0003932675,0.00003014721,0.00001130682,0.0003128693,0.000008590652,0.0001203586,0.99744,0.0001881265,0.0001095332,0.001120789],"study_design_scores_gemma":[0.00007749349,0.0002755338,0.00701813,0.000009075901,0.0000309243,0.003259395,0.00002278906,0.001557779,0.9800526,0.0001047087,0.007578428,0.00001309757],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926516,0.00093268,0.002886769,0.0001582603,0.00005711092,0.00005493167,0.001846474,0.0001142953,0.001297905],"genre_scores_gemma":[0.9876381,0.0006516819,0.004551866,0.00006187663,0.00001579725,0.00006370658,0.003558061,0.00005049318,0.003408305],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001178285,"threshold_uncertainty_score":0.003941774,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02138047013164559,"score_gpt":0.2724832459194593,"score_spread":0.2511027757878137,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}