{"id":"W2122941511","doi":"10.1124/jpet.104.078113","title":"Immunogenicity and Rapid Blood Clearance of Liposomes Containing Polyethylene Glycol-Lipid Conjugates and Nucleic Acid","year":2005,"lang":"en","type":"article","venue":"Journal of Pharmacology and Experimental Therapeutics","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":214,"is_retracted":false,"has_abstract":false,"ca_institutions":"Inimex Pharmaceuticals (Canada)","funders":"","keywords":"Liposome; Immunogenicity; PEGylation; Chemistry; PEG ratio; Polyethylene glycol; Pharmacology; Nucleic acid; Drug carrier; Biochemistry; Immune system; Biology; Drug; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005307943,0.0004341922,0.0002520701,0.000176951,0.0001406285,0.0004130833,0.0002688258,0.0005077728,0.001044104],"category_scores_gemma":[0.000812211,0.0002385792,0.0002408111,0.00009350306,0.000225003,0.0004245002,0.0002004256,0.0008824142,0.0004947489],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003165501,"about_ca_system_score_gemma":0.0003084701,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004206255,"about_ca_topic_score_gemma":0.0001731338,"domain_scores_codex":[0.9997693,0.00006026364,0.00001634879,0.00003435284,0.00005154209,0.00006834446],"domain_scores_gemma":[0.9995928,0.0001327717,0.0000930524,0.00007427435,0.00005898469,0.00004805337],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002253145,0.0001586534,0.000433338,0.0000512666,0.00001356193,0.0001804269,0.00004520109,0.0001266327,0.9918427,0.0003280523,0.0001270084,0.004439984],"study_design_scores_gemma":[0.0001589935,0.001903442,0.003289276,0.000008323304,0.00003477615,0.0006588246,0.00001954478,0.001589603,0.9911001,0.0001009258,0.001128103,0.000008084012],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931971,0.001025614,0.004638734,0.00010188,0.00005174265,0.00004809735,0.00006413796,0.00007191898,0.0008007721],"genre_scores_gemma":[0.9975653,0.0001938472,0.0006620966,0.00005465491,0.00001575093,0.00002296884,0.0001617763,0.0000243711,0.001299299],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001044104,"threshold_uncertainty_score":0.003492832,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01277270779395119,"score_gpt":0.2909965542471064,"score_spread":0.2782238464531552,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}