{"id":"W2122965996","doi":"10.1210/en.2011-2080","title":"The Foxo Family: Partners in Crime or Silent Heroes","year":2012,"lang":"en","type":"letter","venue":"Endocrinology","topic":"FOXO transcription factor regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute","funders":"Institut de Recherche Clinique De Montréal","keywords":"FOXO1; FOXO3; Glucose homeostasis; Gluconeogenesis; Biology; Regulator; Endocrinology; Phenotype; Knockout mouse; Internal medicine; Insulin; Downregulation and upregulation; Gene; Genetics; Transcription factor; Metabolism; Insulin resistance; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009063871,0.0003206897,0.0002652165,0.00008871804,0.00009651179,0.00002735568,0.0004015896,0.0006613053,0.00007455073],"category_scores_gemma":[0.00005853139,0.0002235689,0.000138952,0.00007152973,0.0002499417,0.000004353816,0.00009822256,0.0007442419,0.000115779],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005350879,"about_ca_system_score_gemma":0.00009528432,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006192947,"about_ca_topic_score_gemma":0.000144165,"domain_scores_codex":[0.9979666,0.0002196905,0.0003534083,0.0004609163,0.0001691153,0.0008302731],"domain_scores_gemma":[0.9990916,0.0000638199,0.0001248094,0.0006299537,0.00004646714,0.00004332202],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00012631,0.00003020657,0.0007851189,0.00003403249,0.0001062683,0.00008450658,0.00004715777,0.000008013668,0.03826723,0.0002250979,0.9575446,0.002741451],"study_design_scores_gemma":[0.000436699,0.0001331011,0.004774494,0.000009813373,0.0000253608,0.00005897419,0.0000432225,0.000002064562,0.006357126,0.00006457575,0.987834,0.0002605216],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.2478188,0.03318361,0.0008861666,0.6855945,0.01287793,0.002816925,0.0002386616,0.000269764,0.01631362],"genre_scores_gemma":[0.6373208,0.003964846,0.0002989786,0.3163739,0.008904018,0.0005609331,0.00262467,0.0002494945,0.02970238],"genre_candidate":"commentary","genre_consensus":null,"teacher_disagreement_score":0.389502,"threshold_uncertainty_score":0.9116873,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0364316788454848,"score_gpt":0.297860264806619,"score_spread":0.2614285859611342,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}