{"id":"W2122994961","doi":"10.1128/mcb.00087-10","title":"Zinc Finger Protein Gfi1 Controls the Endotoxin-Mediated Toll-Like Receptor Inflammatory Response by Antagonizing NF-κB p65","year":2010,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Clinical Research Institute","funders":"Canadian Institutes of Health Research; Deutsche Forschungsgemeinschaft","keywords":"Biology; Transactivation; Proinflammatory cytokine; Tumor necrosis factor alpha; Innate immune system; Toll-like receptor; Transcription factor; NFKB1; Cell biology; Molecular biology; TLR4; Nuclear protein; Zinc finger; Signal transduction; Immunology; Immune system; Inflammation; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001022105,0.0004958956,0.000199033,0.0001849972,0.0001532657,0.0002712588,0.0002598676,0.0001951904,0.0006881115],"category_scores_gemma":[0.0001480265,0.00009667559,0.0001092847,0.00008638927,0.0003799553,0.0001501118,0.0001989895,0.0002716548,0.0003476976],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000463908,"about_ca_system_score_gemma":0.0001835825,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006105976,"about_ca_topic_score_gemma":0.0006063138,"domain_scores_codex":[0.9999176,0.00001178602,0.000003190877,0.00002365904,0.00001538471,0.00002835148],"domain_scores_gemma":[0.9999048,0.00001230343,0.00003722595,0.000008013281,0.00001074948,0.00002699839],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001125955,0.00001065644,0.0002601403,0.00001577485,0.000001609934,0.00005301669,0.000008006338,0.00005927348,0.998209,0.0001069742,0.00003706853,0.001125868],"study_design_scores_gemma":[0.00002706491,0.0001850095,0.01160003,0.000007033235,0.00001160171,0.0003918821,0.00004188775,0.00239372,0.9813662,0.0002225512,0.00374637,0.000006838202],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903045,0.002924088,0.004506716,0.0001419126,0.00003187951,0.00001349262,0.0002383869,0.0002156038,0.00162334],"genre_scores_gemma":[0.9943095,0.0008473783,0.001785744,0.00004309712,0.00001212358,0.00001542032,0.0001976806,0.0000269152,0.002762112],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006881115,"threshold_uncertainty_score":0.003365874,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003135817219679417,"score_gpt":0.1926414908395592,"score_spread":0.1895056736198797,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}