{"id":"W2122994961","doi":"10.1128/mcb.00087-10","title":"Zinc Finger Protein Gfi1 Controls the Endotoxin-Mediated Toll-Like Receptor Inflammatory Response by Antagonizing NF-κB p65","year":2010,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Clinical Research Institute","funders":"Canadian Institutes of Health Research; Deutsche Forschungsgemeinschaft","keywords":"Biology; Transactivation; Proinflammatory cytokine; Tumor necrosis factor alpha; Innate immune system; Toll-like receptor; Transcription factor; NFKB1; Cell biology; Molecular biology; TLR4; Nuclear protein; Zinc finger; Signal transduction; Immunology; Immune system; Inflammation; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001329942,0.0003318351,0.0003875068,0.0001295926,0.0004120124,0.00004262303,0.0003484538,0.0007220231,0.0004197302],"category_scores_gemma":[0.000498595,0.000244457,0.0001421114,0.0001224007,0.0006127952,0.00007905542,0.0001545903,0.0007975144,0.0004423218],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002162174,"about_ca_system_score_gemma":0.0001174769,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004047504,"about_ca_topic_score_gemma":0.00000703558,"domain_scores_codex":[0.9968687,0.001527134,0.0004916901,0.00046704,0.00005114906,0.0005943029],"domain_scores_gemma":[0.9987117,0.000380886,0.0002165485,0.0005537209,0.00008807512,0.00004908555],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001570293,0.00004517783,0.0002449518,0.00000950469,0.0001594956,0.00002310686,0.0002152738,2.634744e-7,0.9937544,0.0008088088,0.001265802,0.001902878],"study_design_scores_gemma":[0.00120494,0.0001959842,0.00008196284,0.0000103543,0.00002043367,0.00004714113,0.00006127921,0.000007549199,0.6680649,0.00006124803,0.3300357,0.0002085391],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9896839,0.005979838,0.0006530563,0.001802065,0.0007315065,0.000822433,0.0000360771,0.00009415761,0.0001969755],"genre_scores_gemma":[0.9965838,0.00006523608,0.00006650389,0.0007744081,0.00004068121,0.0001746,0.0004402631,0.00003674143,0.001817834],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3287699,"threshold_uncertainty_score":0.9968666,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003135817219679417,"score_gpt":0.1926414908395592,"score_spread":0.1895056736198797,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}