{"id":"W2123006632","doi":"10.1091/mbc.e03-04-0251","title":"Impaired p53 Expression, Function, and Nuclear Localization in Calreticulin-deficient Cells","year":2004,"lang":"en","type":"article","venue":"Molecular Biology of the Cell","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":74,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; St. Boniface Hospital","funders":"Heart and Stroke Foundation of Canada","keywords":"Biology; Calreticulin; Nuclear protein; Apoptosis; Cell biology; DNA damage; Cell nucleus; Cell cycle; Nuclear export signal; Transcription factor; Mdm2; Nuclear localization sequence; Molecular biology; Cell cycle checkpoint; Gene expression; Gene; Tumor suppressor gene; DNA repair; Regulation of gene expression; DNA; Nucleus; Genetics; Endoplasmic reticulum; Carcinogenesis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001200492,0.0001281184,0.0002054453,0.00008751229,0.00004836568,0.000003629617,0.00009337935,0.0001995817,0.00002456225],"category_scores_gemma":[0.00004054683,0.00009469497,0.00008764157,0.0002262663,0.000218127,0.00001098785,0.00009802313,0.0001708622,0.00001034082],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007774406,"about_ca_system_score_gemma":0.00007413221,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000784459,"about_ca_topic_score_gemma":0.000007592866,"domain_scores_codex":[0.9991143,0.00007392038,0.0002499734,0.0002667112,0.0001093181,0.0001857711],"domain_scores_gemma":[0.9994094,0.000009136026,0.0001054354,0.000349856,0.00006213989,0.00006397366],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008078007,0.0001694343,0.0004965264,0.00004253109,0.00001199462,0.0000115198,0.0002450444,0.003844549,0.994469,0.0004422279,0.0001123861,0.00007402566],"study_design_scores_gemma":[0.002351481,0.0003293041,0.001013279,0.0001221355,0.0000679908,0.00002081573,0.0001066378,0.0003617298,0.9927688,0.001004671,0.00174546,0.0001076646],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9819397,0.001264137,0.01511075,0.0005716738,0.0002406744,0.0003928229,0.000004860974,0.00002449948,0.000450846],"genre_scores_gemma":[0.9985246,0.00004943142,0.0006625151,0.0006841806,0.00001212472,0.000006153181,0.00001247852,0.00002316625,0.00002536576],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01658485,"threshold_uncertainty_score":0.3861549,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004438168135831579,"score_gpt":0.2070354070564309,"score_spread":0.2025972389205993,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}