{"id":"W2123006632","doi":"10.1091/mbc.e03-04-0251","title":"Impaired p53 Expression, Function, and Nuclear Localization in Calreticulin-deficient Cells","year":2004,"lang":"en","type":"article","venue":"Molecular Biology of the Cell","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":74,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; St. Boniface Hospital","funders":"Heart and Stroke Foundation of Canada","keywords":"Biology; Calreticulin; Nuclear protein; Apoptosis; Cell biology; DNA damage; Cell nucleus; Cell cycle; Nuclear export signal; Transcription factor; Mdm2; Nuclear localization sequence; Molecular biology; Cell cycle checkpoint; Gene expression; Gene; Tumor suppressor gene; DNA repair; Regulation of gene expression; DNA; Nucleus; Genetics; Endoplasmic reticulum; Carcinogenesis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001299375,0.0004350786,0.0003852449,0.0003369644,0.0001547263,0.0003836522,0.0002214261,0.0003687993,0.001064137],"category_scores_gemma":[0.0002182446,0.0001602962,0.0001807604,0.000209387,0.0003241279,0.0002342707,0.0001847352,0.0005242549,0.0004531332],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002762927,"about_ca_system_score_gemma":0.0001576523,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005578683,"about_ca_topic_score_gemma":0.0004133652,"domain_scores_codex":[0.9998531,0.00002272217,0.00002564051,0.00003406237,0.00003825391,0.00002623102],"domain_scores_gemma":[0.9997401,0.00005112496,0.00006538782,0.00005213928,0.00002240757,0.00006881394],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006845006,0.00001126505,0.0001133769,0.000008330109,0.00000182198,0.00007222057,0.000005894912,0.00003032081,0.9993126,0.00004219045,0.000008545425,0.0003248979],"study_design_scores_gemma":[0.00002395642,0.0002181697,0.005400009,0.00000388991,0.00001176591,0.0007601316,0.0000235712,0.0009679758,0.9916092,0.00006197187,0.0009153692,0.000003951432],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959064,0.0008859049,0.002106242,0.00006201817,0.00001499732,0.00001402559,0.0004590352,0.00007761068,0.0004738428],"genre_scores_gemma":[0.9956219,0.0004953502,0.001695061,0.00002188221,0.000005834063,0.00002379221,0.0006399782,0.00002663447,0.001469597],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001064137,"threshold_uncertainty_score":0.003559947,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004438168135831579,"score_gpt":0.2070354070564309,"score_spread":0.2025972389205993,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}