{"id":"W2123027432","doi":"10.1158/1535-7163.mct-07-0138","title":"Epithelial to mesenchymal transition predicts gefitinib resistance in cell lines of head and neck squamous cell carcinoma and non–small cell lung carcinoma","year":2007,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":273,"is_retracted":false,"has_abstract":true,"ca_institutions":"Immunovaccine (Canada)","funders":"National Cancer Institute; University of Pittsburgh; AstraZeneca","keywords":"Gefitinib; Erlotinib; Head and neck squamous-cell carcinoma; Cancer research; Epithelial–mesenchymal transition; Epidermal growth factor receptor; Biology; Vimentin; Squamous carcinoma; Medicine; Pathology; Oncology; Carcinoma; Internal medicine; Cancer; Head and neck cancer; Immunohistochemistry; Metastasis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002151067,0.0001913253,0.0003659253,0.0008179013,0.000194016,0.000417847,0.0001221699,0.0003418749,0.001225132],"category_scores_gemma":[0.0005568973,0.0001677783,0.000213931,0.0004664457,0.0001641014,0.0001396318,0.0001580097,0.0002471747,0.0002742031],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002301703,"about_ca_system_score_gemma":0.0001485473,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001916053,"about_ca_topic_score_gemma":0.00305074,"domain_scores_codex":[0.9998162,0.00002727278,0.00002616529,0.00003908687,0.00005533369,0.00003595797],"domain_scores_gemma":[0.9996852,0.0001068544,0.00007640031,0.00002626979,0.00005375786,0.00005155142],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001388725,0.0002275961,0.606431,0.00007774364,0.0001065928,0.0003566758,0.0001521195,0.0005573413,0.3835047,0.00005666201,0.0003440375,0.006796784],"study_design_scores_gemma":[0.00001047582,0.0002543417,0.9745793,0.000003321619,0.0000414865,0.0007539332,0.0001244429,0.001541591,0.02233761,0.00002669978,0.0003205053,0.000006302766],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990491,0.0001660693,0.000174578,0.00001256792,0.000002714006,0.00001527953,0.000321693,0.00001328002,0.0002445641],"genre_scores_gemma":[0.9986863,0.00009279766,0.0002121983,0.0000132791,0.000002603794,0.00002234362,0.0007945771,0.000002485484,0.0001733948],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001916053,"threshold_uncertainty_score":0.004098535,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01401787967718434,"score_gpt":0.2841128916032479,"score_spread":0.2700950119260636,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}