{"id":"W2123063573","doi":"10.1186/bcr2457","title":"Human mammary cancer progression model recapitulates methylation events associated with breast premalignancy","year":2009,"lang":"en","type":"article","venue":"Breast Cancer Research","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research; Occupational Cancer Research Centre","funders":"National Cancer Institute; National Institutes of Health; Susan G. Komen for the Cure; U.S. Department of Defense","keywords":"Epigenetics; Cancer research; DNA methylation; Malignant transformation; Malignancy; Cancer; Tumor progression; Biology; Methylation; Breast cancer; Downregulation and upregulation; Telomerase; Stromal cell; Mammary tumor; Carcinogenesis; Pathology; Medicine; Gene; Gene expression; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001607322,0.0004452694,0.0002680999,0.0003775771,0.0001778065,0.0002009737,0.0002057308,0.0003999993,0.002109374],"category_scores_gemma":[0.0000654086,0.0001419449,0.0002979394,0.0001995863,0.0001691535,0.0001272933,0.0002281516,0.0006774318,0.0005889651],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003960665,"about_ca_system_score_gemma":0.0002891691,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001166534,"about_ca_topic_score_gemma":0.00171057,"domain_scores_codex":[0.9998648,0.00002032309,0.00001051779,0.00003115573,0.0000403422,0.00003296575],"domain_scores_gemma":[0.9999323,0.000007827055,0.00001577094,0.00002017588,0.000008114468,0.00001591705],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0002478393,0.0001175209,0.0003866808,0.00002491556,0.000005274148,0.00009752837,0.00001652718,0.0001175366,0.9975783,0.000152496,0.00006943943,0.001186034],"study_design_scores_gemma":[0.00004752632,0.001787356,0.00537935,0.000008805447,0.00002977788,0.00091317,0.00003014131,0.001771695,0.9830147,0.0001253244,0.006884599,0.000007560745],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9901769,0.001098787,0.004614185,0.0001082371,0.00005224397,0.0001916528,0.001046262,0.0002205077,0.002491345],"genre_scores_gemma":[0.9893412,0.0005937575,0.00280802,0.00005622534,0.000008759222,0.0001873513,0.001610537,0.00002378502,0.005370422],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002109374,"threshold_uncertainty_score":0.007056594,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0703207299781021,"score_gpt":0.422361666256937,"score_spread":0.3520409362788349,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}