{"id":"W2123063573","doi":"10.1186/bcr2457","title":"Human mammary cancer progression model recapitulates methylation events associated with breast premalignancy","year":2009,"lang":"en","type":"article","venue":"Breast Cancer Research","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research; Occupational Cancer Research Centre","funders":"National Cancer Institute; National Institutes of Health; Susan G. Komen for the Cure; U.S. Department of Defense","keywords":"Epigenetics; Cancer research; DNA methylation; Malignant transformation; Malignancy; Cancer; Tumor progression; Biology; Methylation; Breast cancer; Downregulation and upregulation; Telomerase; Stromal cell; Mammary tumor; Carcinogenesis; Pathology; Medicine; Gene; Gene expression; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009577773,0.0002939866,0.0004831513,0.0003529827,0.0003667549,0.00006593068,0.0002505786,0.0001843005,0.000424838],"category_scores_gemma":[0.00002383944,0.0002200657,0.0001220586,0.001045882,0.0001095015,0.0003460932,0.00008455352,0.0006300022,0.00001139155],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009477319,"about_ca_system_score_gemma":0.001095515,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00143361,"about_ca_topic_score_gemma":0.0005464905,"domain_scores_codex":[0.9961889,0.0002213812,0.0003683385,0.0006951374,0.001634908,0.0008913752],"domain_scores_gemma":[0.9977867,0.00003328147,0.0001637687,0.0005323671,0.001090923,0.0003929292],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.003553579,0.002196669,0.05578358,0.0004665673,0.0007379613,0.0001675651,0.001103879,0.001694093,0.1292836,0.0006046747,0.009583052,0.7948248],"study_design_scores_gemma":[0.007465925,0.0009623239,0.9562184,0.006527864,0.0003628788,0.0002843407,0.00009487683,0.003783131,0.02095429,0.00197643,0.0006105507,0.0007589831],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9707716,0.005818922,0.0003559219,0.01549725,0.0001318616,0.00256117,0.0005176935,0.000266791,0.004078825],"genre_scores_gemma":[0.9928467,0.0008397216,0.0004078526,0.0001964028,0.0002874938,0.0003481084,0.0001054894,0.00005975013,0.004908436],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9004349,"threshold_uncertainty_score":0.897402,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0703207299781021,"score_gpt":0.422361666256937,"score_spread":0.3520409362788349,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}