{"id":"W2123072999","doi":"10.1186/1749-8104-3-23","title":"A chemical-genetic strategy reveals distinct temporal requirements for SAD-1 kinase in neuronal polarization and synapse formation","year":2008,"lang":"en","type":"article","venue":"Neural Development","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"National Institute of Neurological Disorders and Stroke; National Institute of Allergy and Infectious Diseases; Natural Sciences and Engineering Research Council of Canada; National Institutes of Health; Damon Runyon Cancer Research Foundation","keywords":"Biology; Neuroscience; Synapse; Caenorhabditis elegans; Biological neural network; Premovement neuronal activity; Cell polarity; Polarity (international relations); Kinase; Cell biology; Gene; Genetics; Cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001017068,0.0001716363,0.0001388778,0.00005042483,0.0001117844,0.00002205525,0.0001062311,0.00009912079,0.000005064498],"category_scores_gemma":[0.00005053809,0.0001760364,0.00002941867,0.00006009891,0.00005132616,0.00001206884,0.00007969683,0.00006117066,0.000002099863],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003389737,"about_ca_system_score_gemma":0.00007627164,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001405321,"about_ca_topic_score_gemma":0.00004092732,"domain_scores_codex":[0.9988803,0.00003611008,0.0003544799,0.0003251748,0.000143906,0.0002600855],"domain_scores_gemma":[0.9996124,0.000007478644,0.00009531623,0.0001398611,0.0000610367,0.00008388854],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00009597555,0.00009863153,0.09928631,0.0000931938,0.0000147726,0.000008858797,0.0004362894,0.0001128053,0.894009,0.000009398002,0.0002957109,0.005539073],"study_design_scores_gemma":[0.001344398,0.0002357759,0.688295,0.00002154018,0.00001200437,0.00006125292,0.00003025888,0.0008320866,0.3075865,0.0001024865,0.001097109,0.0003816031],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951538,0.0001533207,0.004075429,0.00008540167,0.00006689749,0.0004187288,0.00001132506,0.00001154436,0.0000234803],"genre_scores_gemma":[0.9941837,0.00003629252,0.004879834,0.0002131715,0.00005710893,0.00005418848,0.0004063924,0.00002029761,0.0001490485],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5890087,"threshold_uncertainty_score":0.7178556,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02933302498795192,"score_gpt":0.2506053252120058,"score_spread":0.2212723002240539,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}