{"id":"W2123091486","doi":"10.1529/biophysj.104.043380","title":"Consequences of Molecular-Level Ca2+ Channel and Synaptic Vesicle Colocalization for the Ca2+ Microdomain and Neurotransmitter Exocytosis: A Monte Carlo Study","year":2004,"lang":"en","type":"article","venue":"Biophysical Journal","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":55,"is_retracted":false,"has_abstract":false,"ca_institutions":"Simon Fraser University","funders":"","keywords":"Vesicle; Lipid microdomain; Exocytosis; Synaptic vesicle; Colocalization; Biophysics; Neurotransmitter; Active zone; Vesicle fusion; Chemistry; Kiss-and-run fusion; Biology; Cell biology; Membrane; Biochemistry; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001347214,0.0006587901,0.001822745,0.0007222904,0.001808151,0.001579395,0.002042954,0.002250487,0.004118387],"category_scores_gemma":[0.004703714,0.001241755,0.00141414,0.000688385,0.002235963,0.001763985,0.001052008,0.001285591,0.0001894963],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002660138,"about_ca_system_score_gemma":0.002567789,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.02775572,"about_ca_topic_score_gemma":0.01919798,"domain_scores_codex":[0.9996098,0.0001318275,0.00001234981,0.00004088009,0.00007304211,0.0001321651],"domain_scores_gemma":[0.9960704,0.002702515,0.0003426618,0.0002210125,0.000285501,0.0003779804],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0003260637,0.0001056706,0.002284074,0.00004998228,0.00005885781,0.0003656201,0.00005870656,0.9663545,0.002594575,0.02668407,0.0003521547,0.0007656239],"study_design_scores_gemma":[0.00008929658,0.00001969858,0.0004870386,0.000004711254,0.00001927799,0.00003509995,0.00001773212,0.9967875,0.0003175209,0.002155189,0.00005372999,0.00001319169],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9606917,0.0003363889,0.02526126,0.001033368,0.00006702143,0.00008214205,0.0002236648,0.0001593226,0.01214516],"genre_scores_gemma":[0.9948934,0.0001096131,0.003495906,0.0001302536,0.00002234478,0.00005399539,0.00006178339,0.00008258935,0.001150143],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02775572,"threshold_uncertainty_score":0.0551883,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01756741884172918,"score_gpt":0.2379853201712734,"score_spread":0.2204179013295442,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}