{"id":"W2123091486","doi":"10.1529/biophysj.104.043380","title":"Consequences of Molecular-Level Ca2+ Channel and Synaptic Vesicle Colocalization for the Ca2+ Microdomain and Neurotransmitter Exocytosis: A Monte Carlo Study","year":2004,"lang":"en","type":"article","venue":"Biophysical Journal","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":55,"is_retracted":false,"has_abstract":false,"ca_institutions":"Simon Fraser University","funders":"","keywords":"Vesicle; Lipid microdomain; Exocytosis; Synaptic vesicle; Colocalization; Biophysics; Neurotransmitter; Active zone; Vesicle fusion; Chemistry; Kiss-and-run fusion; Biology; Cell biology; Membrane; Biochemistry; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001301752,0.0001121215,0.0001372911,0.00002116358,0.0001271121,0.00003123096,0.00008321874,0.0000588921,6.202533e-7],"category_scores_gemma":[0.00001357137,0.0000808684,0.00007197077,0.00004805751,0.0002079243,0.000006153241,0.00001626172,0.00007509789,1.321551e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006368673,"about_ca_system_score_gemma":0.00004298296,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005435444,"about_ca_topic_score_gemma":0.00003079678,"domain_scores_codex":[0.9993519,0.00004303271,0.0001862272,0.0001784078,0.0001039244,0.0001364908],"domain_scores_gemma":[0.9996733,0.00001527212,0.00007640229,0.00009688819,0.00007449783,0.00006365232],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001601866,0.000112713,0.0004818939,0.00001840824,0.0001021784,0.00001303751,0.0002663163,0.0002547824,0.998319,0.00005892229,0.000002510982,0.0002100314],"study_design_scores_gemma":[0.00253147,0.001430448,0.01236313,0.00003298954,0.0002271457,0.0001357168,0.0005547677,0.0004461445,0.9817526,0.000219405,0.0001225372,0.000183686],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9533495,0.0006177321,0.04524538,0.0003687423,0.00004967522,0.0003454574,0.00001943108,0.000002755615,0.000001365648],"genre_scores_gemma":[0.999383,0.0001993932,0.0001396955,0.0001403785,0.00008747919,0.00001834139,0.00001362448,0.00001214772,0.000005910371],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04603356,"threshold_uncertainty_score":0.3297718,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01756741884172918,"score_gpt":0.2379853201712734,"score_spread":0.2204179013295442,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}