{"id":"W2123103571","doi":"10.1371/journal.pone.0097608","title":"APOE ε4 Is Associated with Disproportionate Progressive Hippocampal Atrophy in AD","year":2014,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Engineering and Physical Sciences Research Council; Novartis Pharma; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; University of California, Los Angeles; Genentech; National Institutes of Health; IXICO; H. Lundbeck A/S; Servier; Eisai; FP7 Information and Communication Technologies; Wolfson Foundation; Brain Research Trust; National Institute on Aging; National Institute for Health and Care Research; Northern California Institute for Research and Education; Pfizer; Biogen; BioClinica; F. Hoffmann-La Roche; University College London; Medpace; Eli Lilly and Company; Bristol-Myers Squibb; Novartis Pharmaceuticals Corporation; Sanofi; Synarc; Alzheimer's Disease Neuroimaging Initiative; Meso Scale Diagnostics; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Atrophy; Hippocampal formation; Medicine; Temporal lobe; Internal medicine; Cardiology; Hippocampus; Apolipoprotein E; Alzheimer's disease; Pittsburgh compound B; Psychology; Pathology; Disease; Psychiatry; Epilepsy","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001053357,0.0004952977,0.0003920261,0.001121696,0.0003471321,0.0005998328,0.0004089216,0.0005166002,0.002811589],"category_scores_gemma":[0.003488964,0.000321036,0.0005566831,0.0008866603,0.0004198666,0.0003422699,0.000415559,0.0003916062,0.0002635331],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001965717,"about_ca_system_score_gemma":0.0002816348,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003647787,"about_ca_topic_score_gemma":0.002356669,"domain_scores_codex":[0.9995224,0.0001623471,0.00006232045,0.0001285241,0.00006844067,0.000055979],"domain_scores_gemma":[0.9977354,0.0006029176,0.001193285,0.0001716559,0.0001441006,0.000152582],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00177529,0.00007921974,0.9909697,0.00003695951,0.0003372992,0.0005347833,0.0001058948,0.00007676271,0.002674721,0.00004785599,0.00006818964,0.003293338],"study_design_scores_gemma":[0.00001541305,0.0001745252,0.9979149,0.000008658278,0.0001713226,0.0009422345,0.00008000755,0.0001864891,0.0003247641,0.0001020657,0.00007573193,0.000003839912],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990469,0.0004780563,0.0001245571,0.0000359364,0.000006598426,0.000002606068,0.00006401098,0.000007220689,0.0002342143],"genre_scores_gemma":[0.9994123,0.0001294093,0.0001327759,0.0000119411,0.000009765619,0.00000228305,0.0000806887,0.000002914173,0.0002179358],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003647787,"threshold_uncertainty_score":0.009405673,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0265902925133068,"score_gpt":0.2695830043760873,"score_spread":0.2429927118627805,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}