{"id":"W2123121631","doi":"10.1152/physiolgenomics.90328.2008","title":"Targeted transgenesis at the HPRT locus: an efficient strategy to achieve tightly controlled in vivo conditional expression with the tet system","year":2009,"lang":"en","type":"article","venue":"Physiological Genomics","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Royal Victoria Hospital; McGill University Health Centre; Royal Victoria Regional Health Centre","funders":"","keywords":"Biology; Transgenesis; Genetics; In vivo; Locus (genetics); Computational biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004211678,0.000691411,0.0004726841,0.0004112847,0.0002078326,0.00047572,0.0006059229,0.0005558311,0.001378097],"category_scores_gemma":[0.0002123916,0.0003299375,0.0004033012,0.0003134192,0.000451379,0.0003328736,0.0005208151,0.00125825,0.001221017],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003573513,"about_ca_system_score_gemma":0.0003399976,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004373277,"about_ca_topic_score_gemma":0.0005211328,"domain_scores_codex":[0.9995769,0.00006007331,0.00004381151,0.0001198386,0.0001445255,0.000054835],"domain_scores_gemma":[0.9998156,0.00003604017,0.00005946878,0.00003434461,0.00002098695,0.00003360287],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000006893895,0.000007245088,0.00001627954,0.00002045442,0.000002874014,0.00002683886,0.000007573651,0.00003185471,0.9986935,0.0001264351,0.00002602992,0.001034072],"study_design_scores_gemma":[0.00000986898,0.0000930402,0.0004478509,0.000004693471,0.00001531633,0.0003123191,0.000006979446,0.0005327486,0.9938663,0.00006099149,0.004643688,0.000006407473],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.4916121,0.004316287,0.4929802,0.000501627,0.0002475346,0.0007246315,0.001624549,0.002448007,0.00554502],"genre_scores_gemma":[0.7800522,0.006056312,0.1929991,0.0003369707,0.00009982081,0.000784219,0.00293809,0.00093134,0.015802],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.001378097,"threshold_uncertainty_score":0.004610181,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0121928302606895,"score_gpt":0.2354643964927989,"score_spread":0.2232715662321094,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}