{"id":"W2123133140","doi":"10.1200/jco.2003.11.126","title":"Superiority of Oxaliplatin and Fluorouracil-Leucovorin Compared With Either Therapy Alone in Patients With Progressive Colorectal Cancer After Irinotecan and Fluorouracil-Leucovorin: Interim Results of a Phase III Trial","year":2003,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Colorectal Cancer Treatments and Studies","field":"Medicine","cited_by":645,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research","funders":"National Cancer Institute; Sanofi","keywords":"Medicine; Oxaliplatin; Irinotecan; Fluorouracil; Internal medicine; Colorectal cancer; Gastroenterology; Interim analysis; Bolus (digestion); Oncology; Chemotherapy; Surgery; Cancer; Clinical trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001053713,0.0002714481,0.002383494,0.000137822,0.00003738355,0.000009060866,0.0000739983,0.0002108161,0.00005746009],"category_scores_gemma":[0.0004865907,0.000155386,0.0001461768,0.0001983837,0.0006522878,0.0001324054,0.00004372423,0.000544913,1.338229e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001678297,"about_ca_system_score_gemma":0.0008639966,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002878081,"about_ca_topic_score_gemma":0.001238281,"domain_scores_codex":[0.9965281,0.0004307329,0.002035191,0.0003145482,0.0004288731,0.0002624924],"domain_scores_gemma":[0.9965268,0.0007253302,0.001707419,0.0001459599,0.0006637995,0.0002307058],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.516697,0.004949277,0.4402175,0.00003134008,0.0007235322,0.0001835543,0.001220978,0.000001597593,0.00007299802,0.000002741387,0.00001744784,0.03588197],"study_design_scores_gemma":[0.3187706,0.1123901,0.5664096,0.0003029619,0.0002760507,0.00005309722,0.0003777724,0.000008446112,0.0006109278,0.000009441926,0.0006679326,0.000123068],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962791,0.001640682,0.000003857191,0.0003733655,0.0002590794,0.001112009,0.00005445487,0.00000447434,0.0002729291],"genre_scores_gemma":[0.9979439,0.0006840274,0.001037806,0.00008493537,0.0001383487,0.00006223228,0.00000378129,0.00001916534,0.00002583945],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1979265,"threshold_uncertainty_score":0.6336455,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06821672524614635,"score_gpt":0.421301268873285,"score_spread":0.3530845436271386,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}