{"id":"W2123133140","doi":"10.1200/jco.2003.11.126","title":"Superiority of Oxaliplatin and Fluorouracil-Leucovorin Compared With Either Therapy Alone in Patients With Progressive Colorectal Cancer After Irinotecan and Fluorouracil-Leucovorin: Interim Results of a Phase III Trial","year":2003,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Colorectal Cancer Treatments and Studies","field":"Medicine","cited_by":645,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research","funders":"National Cancer Institute; Sanofi","keywords":"Medicine; Oxaliplatin; Irinotecan; Fluorouracil; Internal medicine; Colorectal cancer; Gastroenterology; Interim analysis; Bolus (digestion); Oncology; Chemotherapy; Surgery; Cancer; Clinical trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002866124,0.001178623,0.002136734,0.0004291502,0.0003563844,0.001048682,0.0008047191,0.001282319,0.003384128],"category_scores_gemma":[0.001882955,0.0004510879,0.001779336,0.0004283985,0.0008442835,0.0008439642,0.000325791,0.002442013,0.0006552828],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008092414,"about_ca_system_score_gemma":0.001251504,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006176193,"about_ca_topic_score_gemma":0.001877695,"domain_scores_codex":[0.9990149,0.0006363885,0.00005615536,0.0001171475,0.00005000647,0.0001253588],"domain_scores_gemma":[0.9984712,0.0004996161,0.0003414642,0.0001030838,0.00005758132,0.0005269499],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9625534,0.007076633,0.001962875,0.0002247465,0.000845509,0.00005010963,0.00005987456,0.0003508057,0.001990145,0.00005613389,0.0005151442,0.02431445],"study_design_scores_gemma":[0.796941,0.1957691,0.004869753,0.00003182735,0.0006137205,0.00007347066,0.00002021509,0.0005254102,0.0005474258,0.0000839058,0.0005108792,0.00001329884],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942947,0.002876676,0.0002437138,0.0004545707,0.0001921791,0.0006454052,0.0003090274,0.00004467776,0.0009391262],"genre_scores_gemma":[0.9948344,0.001316632,0.0007601549,0.0006068256,0.000318827,0.0007204339,0.000591441,0.00001010847,0.0008411412],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003384128,"threshold_uncertainty_score":0.01515764,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06821672524614635,"score_gpt":0.421301268873285,"score_spread":0.3530845436271386,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}