{"id":"W2123152742","doi":"10.3324/haematol.13733","title":"Shwachman-Diamond syndrome neutrophils have altered chemoattractant-induced F-actin polymerization and polarization characteristics","year":2009,"lang":"en","type":"article","venue":"Haematologica","topic":"Blood disorders and treatments","field":"Biochemistry, Genetics and Molecular Biology","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Universiteit van Amsterdam","keywords":"Chemotaxis; Actin; Cytoskeleton; Immunology; Neutropenia; Wiskott–Aldrich syndrome; Cell biology; Medicine; Biology; Internal medicine; Cell; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004156816,0.0002092493,0.0002562488,0.00004233078,0.0001324094,0.00005127953,0.00009342242,0.0002208895,0.00001433931],"category_scores_gemma":[0.00004309009,0.0001875002,0.00005083947,0.00006715237,0.00003678604,0.00001131608,0.00003693208,0.00007515692,0.000006916767],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006490761,"about_ca_system_score_gemma":0.0000211916,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009679017,"about_ca_topic_score_gemma":0.000003372552,"domain_scores_codex":[0.9990083,0.00004194053,0.000229852,0.0003804943,0.00009187038,0.0002475276],"domain_scores_gemma":[0.9994745,0.000006827798,0.0001522905,0.0002421667,0.0000375122,0.00008674474],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001345941,0.0004398032,0.02618099,0.00002207546,0.00007945567,0.00008635398,0.00005966875,5.41426e-7,0.9592586,0.0004224354,0.00008355796,0.01323195],"study_design_scores_gemma":[0.002000732,0.001956236,0.5443906,0.0000372047,0.0001281646,0.001010211,0.00009229347,0.0001290883,0.4482565,0.0005478821,0.0007865102,0.0006646414],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997919,0.0004175153,0.0002825245,0.0004958161,0.00007849327,0.0002419694,0.00001996846,0.00003270791,0.0005119943],"genre_scores_gemma":[0.9983568,0.0001661096,0.0002928094,0.0004927493,0.00004804711,0.00001206793,0.0004879442,0.00001589808,0.0001275469],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5182096,"threshold_uncertainty_score":0.7646035,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01198996366644297,"score_gpt":0.2399801151451804,"score_spread":0.2279901514787375,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}