{"id":"W2123158115","doi":"10.1158/1078-0432.ccr-06-1863","title":"Phase I Trial of 17-Allylamino-17-Demethoxygeldanamycin in Patients with Advanced Cancer","year":2007,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":212,"is_retracted":false,"has_abstract":true,"ca_institutions":"Immunovaccine (Canada)","funders":"National Cancer Institute; U.S. Public Health Service","keywords":"Medicine; Dosing; Nausea; Pharmacokinetics; Pharmacodynamics; Toxicity; Adverse effect; Tolerability; Pharmacology; Internal medicine; Anesthesia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006827908,0.001139531,0.001565024,0.0002524733,0.0002815365,0.0005746739,0.0006177933,0.0009365973,0.002490832],"category_scores_gemma":[0.0005896754,0.0002837716,0.0005210196,0.0003153738,0.0007749245,0.0004157503,0.0002463947,0.002257721,0.0005090658],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008603394,"about_ca_system_score_gemma":0.001467847,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007740917,"about_ca_topic_score_gemma":0.001780449,"domain_scores_codex":[0.9997832,0.00008894102,0.00001132606,0.00003980831,0.00002417644,0.00005258267],"domain_scores_gemma":[0.9995789,0.00008739792,0.00009407472,0.00002974211,0.00002277746,0.0001872324],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5418643,0.05304864,0.01229586,0.001694782,0.001050336,0.0006864162,0.0005448492,0.009526061,0.1374242,0.0006782131,0.007207541,0.2339789],"study_design_scores_gemma":[0.4302169,0.5354658,0.01380149,0.00006895083,0.0003334955,0.0005364437,0.00006687852,0.002505035,0.01111904,0.0002705457,0.005589595,0.00002581965],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924693,0.002941953,0.0004655659,0.0003073062,0.00009902161,0.001447489,0.0003930183,0.00008064823,0.001795789],"genre_scores_gemma":[0.9913927,0.001659824,0.001739072,0.0004606652,0.0001326693,0.001806819,0.001098718,0.00002043635,0.001688924],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002490832,"threshold_uncertainty_score":0.00833261,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.13591248393524,"score_gpt":0.5333629320324956,"score_spread":0.3974504480972556,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}