{"id":"W2123176392","doi":"10.1158/2326-6066.cir-14-0191","title":"Identification and Characterization of MEDI4736, an Antagonistic Anti–PD-L1 Monoclonal Antibody","year":2015,"lang":"en","type":"article","venue":"Cancer Immunology Research","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":409,"is_retracted":false,"has_abstract":true,"ca_institutions":"Phoenix Technologies (Canada); Arbutus Biopharma (Canada); University of British Columbia","funders":"AstraZeneca","keywords":"Monoclonal antibody; Cancer research; CD80; Cancer immunotherapy; Antibody; T cell; Immunotherapy; In vivo; Cytotoxicity; PD-L1; Immune system; Chemistry; In vitro; Cytotoxic T cell; Pharmacology; Immunology; Biology; CD40; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001883341,0.0005121847,0.0002973549,0.0004147004,0.000133122,0.0002799245,0.0003104414,0.0003470582,0.001010588],"category_scores_gemma":[0.0001984503,0.000167454,0.0003950338,0.0001936998,0.0001331177,0.000166273,0.0001604578,0.0005038958,0.0006609783],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004112532,"about_ca_system_score_gemma":0.0002827012,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004411354,"about_ca_topic_score_gemma":0.0003850014,"domain_scores_codex":[0.9998828,0.00001877069,0.000009631999,0.00001811288,0.00003797263,0.00003264796],"domain_scores_gemma":[0.9999058,0.00001295586,0.0000173728,0.000009762804,0.0000190315,0.00003496195],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001705363,0.0001328231,0.0004451008,0.00005390907,0.00001309733,0.00007582659,0.00001794661,0.0004332573,0.9911351,0.0001348829,0.0001682001,0.007219227],"study_design_scores_gemma":[0.0001602249,0.002837029,0.005976652,0.00001654706,0.00007632567,0.001283516,0.00001697308,0.003392621,0.9696788,0.0001032768,0.01644677,0.00001127535],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9792922,0.004695539,0.0108255,0.0002868295,0.00003578296,0.0003367124,0.001048371,0.0000973476,0.003381773],"genre_scores_gemma":[0.9782874,0.003464975,0.01007501,0.0002409908,0.00004831114,0.0001257333,0.004065881,0.00002842101,0.003663331],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001010588,"threshold_uncertainty_score":0.003380775,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09984791139134354,"score_gpt":0.4369662327177876,"score_spread":0.3371183213264441,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}