{"id":"W2123176392","doi":"10.1158/2326-6066.cir-14-0191","title":"Identification and Characterization of MEDI4736, an Antagonistic Anti–PD-L1 Monoclonal Antibody","year":2015,"lang":"en","type":"article","venue":"Cancer Immunology Research","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":409,"is_retracted":false,"has_abstract":true,"ca_institutions":"Phoenix Technologies (Canada); Arbutus Biopharma (Canada); University of British Columbia","funders":"AstraZeneca","keywords":"Monoclonal antibody; Cancer research; CD80; Cancer immunotherapy; Antibody; T cell; Immunotherapy; In vivo; Cytotoxicity; PD-L1; Immune system; Chemistry; In vitro; Cytotoxic T cell; Pharmacology; Immunology; Biology; CD40; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001238845,0.0001157843,0.0002959787,0.0003262711,0.0001222148,0.00003011038,0.0001649101,0.000168055,0.0001225718],"category_scores_gemma":[0.0001090998,0.0001046705,0.00003594179,0.0004778263,0.0008764258,0.0002025937,0.00006906702,0.000302225,0.0000116492],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001608338,"about_ca_system_score_gemma":0.0006029046,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004502577,"about_ca_topic_score_gemma":0.00001326082,"domain_scores_codex":[0.9983486,0.0002333321,0.0003633694,0.0003301827,0.000399102,0.000325408],"domain_scores_gemma":[0.9985959,0.00005234905,0.0001213442,0.0003909705,0.0007186949,0.0001207187],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002593265,0.0001313977,0.03324335,0.0000724006,0.000149801,0.000009617264,0.0006738668,2.88941e-7,0.9467163,0.000128181,0.0001112715,0.01617028],"study_design_scores_gemma":[0.002754759,0.0009078312,0.76369,0.0001247417,0.0000436533,0.00009179986,0.0004833652,0.0003238702,0.2252627,0.0001318842,0.006050597,0.000134751],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930021,0.00404034,0.0001035484,0.001798729,0.0003963874,0.0004176078,0.00004856214,0.0000291693,0.0001635491],"genre_scores_gemma":[0.9939095,0.004768263,0.00003165737,0.00008285209,0.0001565888,0.00006110642,0.0002858875,0.00002196731,0.0006822207],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7304466,"threshold_uncertainty_score":0.426834,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09984791139134354,"score_gpt":0.4369662327177876,"score_spread":0.3371183213264441,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}