{"id":"W2123197724","doi":"10.1096/fj.10-171959","title":"Fine‐tuning the stimulation of MLL1 methyltransferase activity by a histone H3‐based peptide mimetic","year":2010,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Canadian Institutes of Health Research","keywords":"Histone H3; Histone methyltransferase; Methyltransferase; Methylation; Acetylation; Moiety; Histone methylation; Histone; Chemistry; Peptide; Epigenetics; Biochemistry; Cell biology; Biology; Stereochemistry; DNA methylation; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001294226,0.0002999413,0.000168979,0.0001182913,0.0001118373,0.0002048353,0.0002364853,0.0002659588,0.001169641],"category_scores_gemma":[0.0001024734,0.0001104964,0.0002056404,0.0001074593,0.0001415079,0.0001751891,0.0001705171,0.0004558911,0.0002877668],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002787731,"about_ca_system_score_gemma":0.00009732437,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002040338,"about_ca_topic_score_gemma":0.0003042105,"domain_scores_codex":[0.9999299,0.00001213978,0.00000631746,0.00001295175,0.00001761429,0.00002105848],"domain_scores_gemma":[0.9999579,0.000008922611,0.00001197896,0.000004405222,0.000004632006,0.00001214283],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001322748,0.00002876305,0.00005834628,0.00002424333,0.000004241094,0.00002008065,0.000004671908,0.00009304017,0.9981174,0.00004968487,0.00004088927,0.001426296],"study_design_scores_gemma":[0.00003439934,0.000330606,0.000475078,0.000001231514,0.000006467816,0.00009807472,0.000003973511,0.0006217977,0.9972965,0.00001634488,0.001112873,0.000002723227],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924169,0.001679463,0.00381492,0.0001281158,0.00003845124,0.00006050309,0.0002227306,0.0001005485,0.001538497],"genre_scores_gemma":[0.9938852,0.0005617875,0.003836637,0.00007018289,0.000009277921,0.00004453092,0.0001496802,0.00001203204,0.001430817],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001169641,"threshold_uncertainty_score":0.003912866,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01296720506407424,"score_gpt":0.276437526496247,"score_spread":0.2634703214321727,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}