{"id":"W2123212032","doi":"10.1084/jem.20081188","title":"Transient high glucose causes persistent epigenetic changes and altered gene expression during subsequent normoglycemia","year":2008,"lang":"en","type":"article","venue":"The Journal of Experimental Medicine","topic":"Peroxisome Proliferator-Activated Receptors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1090,"is_retracted":false,"has_abstract":true,"ca_institutions":"Juvenile Diabetes Research Foundation","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Medical Research Council; Directorate for Biological Sciences; National Health and Medical Research Council; National Heart Foundation of Australia; COMSATS Institute of Information Technology","keywords":"Epigenetics; Endocrinology; Internal medicine; Diabetes mellitus; Gene expression; Biology; Medicine; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000109152,0.0001609804,0.0001733703,0.0001448497,0.00008210593,0.0003007084,0.0001021514,0.0001306408,0.0007616582],"category_scores_gemma":[0.0001410593,0.0001189065,0.0001928388,0.0001190383,0.0002489364,0.0001369761,0.0002115077,0.0003495677,0.0001105067],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002404853,"about_ca_system_score_gemma":0.0001102703,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003362433,"about_ca_topic_score_gemma":0.0004829814,"domain_scores_codex":[0.9998946,0.00001378942,0.000006536249,0.000029727,0.00002001307,0.00003528684],"domain_scores_gemma":[0.9998772,0.00002068075,0.00004239928,0.0000241134,0.000008452904,0.00002703521],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004911165,0.00007371665,0.003427654,0.00002640591,0.00001594852,0.0001737402,0.00003232044,0.00009644382,0.9904461,0.00016682,0.00006526544,0.004984392],"study_design_scores_gemma":[0.00004710475,0.001617895,0.1792913,0.0000165287,0.00007518127,0.001345391,0.0002708588,0.001502428,0.8131633,0.0007346877,0.001915732,0.00001955008],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975866,0.0004270496,0.001462271,0.00003757418,0.0000150897,0.000004799707,0.00008376807,0.00004298302,0.0003398219],"genre_scores_gemma":[0.9985926,0.0003295228,0.0003899342,0.00003917662,0.000008373239,0.00001127971,0.0001206912,0.000008808357,0.0004997189],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007616582,"threshold_uncertainty_score":0.002547979,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01849348108246427,"score_gpt":0.2499994525737425,"score_spread":0.2315059714912782,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}