{"id":"W2123239729","doi":"10.1128/iai.00993-10","title":"An<i>In Vivo</i>High-Throughput Screening Approach Targeting the Type IV Secretion System Component VirB8 Identified Inhibitors of<i>Brucella abortus</i>2308 Proliferation","year":2010,"lang":"en","type":"article","venue":"Infection and Immunity","topic":"Brucella: diagnosis, epidemiology, treatment","field":"Veterinary","cited_by":78,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; McMaster University; Juravinski Cancer Centre","funders":"National Institutes of Health; McMaster University; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; Bristol-Myers Squibb","keywords":"Biology; Secretion; Effector; Virulence; Microbiology; Brucella; In vivo; Type three secretion system; Cell biology; Immunology; Gene; Genetics; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002352478,0.0002676616,0.0004012794,0.0001585674,0.0005051738,0.00007943452,0.0001396116,0.0002907219,0.00004151795],"category_scores_gemma":[0.0002152295,0.0002164021,0.00008837008,0.0003254922,0.0001774101,0.0003310681,0.00009761289,0.0007117215,0.00001288772],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001001322,"about_ca_system_score_gemma":0.00003434322,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01015489,"about_ca_topic_score_gemma":0.0004129636,"domain_scores_codex":[0.9970351,0.001360018,0.0007444503,0.000382759,0.0001937606,0.0002838745],"domain_scores_gemma":[0.9984526,0.0003350276,0.0004297183,0.0005226952,0.0001786893,0.00008123662],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0004284182,0.0007148873,0.2655033,0.0002512721,0.0001060697,0.000006744265,0.001431377,0.001144711,0.7271836,0.001668303,0.0004422072,0.001119143],"study_design_scores_gemma":[0.003108614,0.001825611,0.8589814,0.0003525172,0.0002143866,0.000347367,0.00248389,0.08210129,0.04658501,0.0002427887,0.002900462,0.0008566053],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951696,0.0001528817,0.001761749,0.00008992817,0.001264028,0.0008245755,0.00001717287,0.0001545689,0.0005655371],"genre_scores_gemma":[0.9981942,0.000126636,0.001038417,0.00006899222,0.0002367597,0.0001154472,0.0001762509,0.0000318226,0.00001147805],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6805986,"threshold_uncertainty_score":0.9964366,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03804527244206506,"score_gpt":0.3050089681275557,"score_spread":0.2669636956854906,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}