{"id":"W2123239729","doi":"10.1128/iai.00993-10","title":"An<i>In Vivo</i>High-Throughput Screening Approach Targeting the Type IV Secretion System Component VirB8 Identified Inhibitors of<i>Brucella abortus</i>2308 Proliferation","year":2010,"lang":"en","type":"article","venue":"Infection and Immunity","topic":"Brucella: diagnosis, epidemiology, treatment","field":"Veterinary","cited_by":78,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; McMaster University; Juravinski Cancer Centre","funders":"National Institutes of Health; McMaster University; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; Bristol-Myers Squibb","keywords":"Biology; Secretion; Effector; Virulence; Microbiology; Brucella; In vivo; Type three secretion system; Cell biology; Immunology; Gene; Genetics; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001766036,0.0008669532,0.0006118553,0.0003501823,0.0001700181,0.0004100994,0.0003278705,0.0003873532,0.001369689],"category_scores_gemma":[0.0001080422,0.000194248,0.0004009668,0.0002734173,0.0001712561,0.000132683,0.0001770687,0.0007110782,0.0005412746],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004418024,"about_ca_system_score_gemma":0.000266393,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00117353,"about_ca_topic_score_gemma":0.002864281,"domain_scores_codex":[0.9998534,0.00003380607,0.000008823316,0.00002842091,0.00004450251,0.00003106749],"domain_scores_gemma":[0.9999365,0.00001483582,0.00001475258,0.000006305505,0.00001457742,0.00001312009],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00016051,0.0001331488,0.0001197729,0.00007633823,0.0000157269,0.0000422112,0.000009002484,0.0002904703,0.9961485,0.00005986779,0.0003055589,0.002638839],"study_design_scores_gemma":[0.0001215136,0.002564688,0.001936657,0.00001127713,0.00007130791,0.0003031527,0.00001716817,0.001669953,0.9876662,0.00004013645,0.00558265,0.00001525051],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9567091,0.008618147,0.01693544,0.0007985499,0.0001662826,0.0006471914,0.003624884,0.0006798905,0.01182051],"genre_scores_gemma":[0.9596975,0.006908032,0.01398625,0.0005932294,0.0000490143,0.0004162236,0.005757607,0.00010639,0.01248583],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001369689,"threshold_uncertainty_score":0.004582047,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03804527244206506,"score_gpt":0.3050089681275557,"score_spread":0.2669636956854906,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}