{"id":"W2123242217","doi":"10.1158/1541-7786.mcr-12-0307","title":"Cancer-Associated Fibroblasts Drive the Progression of Metastasis through both Paracrine and Mechanical Pressure on Cancer Tissue","year":2012,"lang":"en","type":"review","venue":"Molecular Cancer Research","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":516,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network; Mount Sinai Hospital","funders":"Creations of Advanced Catalytic Transformation for the Sustainable Manufacturing at Low Energy, Low Environmental Load; National Institute of Environmental Health Sciences","keywords":"Cancer-Associated Fibroblasts; Metastasis; Cancer; Tumor microenvironment; Paracrine signalling; Cancer research; Cancer cell; Carcinogenesis; Biology; Stroma; Tumor progression; Immunology; Tumor cells; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001500365,0.0007192182,0.002629634,0.0002853225,0.0002678785,0.00006190736,0.0005489437,0.0005150896,0.0009800295],"category_scores_gemma":[0.0001756962,0.0004379998,0.0005537986,0.001371376,0.0004934293,0.00009250781,0.0005592022,0.001954654,0.00001121773],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005136037,"about_ca_system_score_gemma":0.001778868,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.008214786,"about_ca_topic_score_gemma":0.0009758293,"domain_scores_codex":[0.9932754,0.00131722,0.0008513391,0.001060849,0.002245468,0.001249712],"domain_scores_gemma":[0.9969672,0.0003682123,0.0005737576,0.0011089,0.0005714159,0.0004105131],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003095884,0.0003522926,0.00001314692,0.01834047,0.002843593,0.00008339484,0.0002241575,0.000009715984,0.001163115,0.0003944999,0.003262066,0.973004],"study_design_scores_gemma":[0.0008923043,0.0007365284,0.00001321255,0.0245355,0.005631739,0.00002123667,0.00003228818,0.000006173024,0.01235434,0.00002981724,0.9553672,0.0003796635],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000331258,0.9926177,0.0000270763,0.001088612,0.0003335018,0.003976714,0.001077642,0.00003780649,0.0005097149],"genre_scores_gemma":[0.004499181,0.9892167,0.0001758694,0.0001406559,0.000425864,0.003817413,0.0001040069,0.0002002623,0.001420069],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9726243,"threshold_uncertainty_score":0.9999332,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1597587769204382,"score_gpt":0.5014731977563605,"score_spread":0.3417144208359223,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}