{"id":"W2123258519","doi":"10.3390/ph3061739","title":"Opportunities to Target Specific Contractile Abnormalities with Smooth Muscle Protein Kinase Inhibitors","year":2010,"lang":"en","type":"review","venue":"Pharmaceuticals","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research; Alberta Innovates; University of Calgary","keywords":"Fasudil; Rho-associated protein kinase; Kinase; Protein kinase A; Contraction (grammar); Muscle contraction; Vasoconstriction; Motility; Cell biology; Vascular smooth muscle; Medicine; Myocyte; Biology; Internal medicine; Smooth muscle","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007002402,0.0005963359,0.000882693,0.0006676837,0.00022552,0.0009247128,0.0005511367,0.001039667,0.01008976],"category_scores_gemma":[0.0006781514,0.0001792263,0.001051091,0.0003290423,0.000339461,0.000898795,0.0006048566,0.003264995,0.003011745],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003465609,"about_ca_system_score_gemma":0.0004601135,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002358264,"about_ca_topic_score_gemma":0.0009740917,"domain_scores_codex":[0.9997008,0.00007643086,0.00002946768,0.00005042573,0.00008493423,0.00005801006],"domain_scores_gemma":[0.9997622,0.00008736045,0.00004348676,0.00001320934,0.00005590034,0.00003777471],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001464768,0.0009228855,0.0007630929,0.009430105,0.0004539299,0.001612308,0.0002119726,0.0008557559,0.08402961,0.02029658,0.08957683,0.7903822],"study_design_scores_gemma":[0.0007365614,0.001644704,0.001328109,0.001196949,0.0003614394,0.002314281,0.0001033106,0.0007776012,0.01767318,0.007615072,0.9661899,0.00005900794],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01579525,0.9192837,0.01462272,0.01548548,0.005229689,0.0003478444,0.0009434344,0.0005917816,0.02770013],"genre_scores_gemma":[0.09701549,0.8382502,0.01459385,0.01441802,0.00470178,0.0005956155,0.002162068,0.0002342861,0.02802878],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.01008976,"threshold_uncertainty_score":0.03375357,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08376491274838553,"score_gpt":0.3470857088649119,"score_spread":0.2633207961165263,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}