{"id":"W2123303925","doi":"10.3324/haematol.2014.112821","title":"Alloantibodies to therapeutic factor VIII in hemophilia A: the role of von Willebrand factor in regulating factor VIII immunogenicity","year":2015,"lang":"en","type":"review","venue":"Haematologica","topic":"Hemophilia Treatment and Research","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Grifols; Swedish Orphan Biovitrum; Biogen; Pfizer","keywords":"Von Willebrand factor; Immunogenicity; Immunology; Antibody; Factor IX; Antigen; Immune system; Recombinant DNA; Medicine; Biology; Internal medicine; Genetics; Gene; Platelet","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004375936,0.0004791408,0.001025152,0.002591614,0.0002333712,0.0008367004,0.0005043465,0.0007920223,0.003020506],"category_scores_gemma":[0.0009279444,0.0001665513,0.0004738611,0.002118207,0.0003619222,0.000822694,0.0004460138,0.000993927,0.00105089],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003282064,"about_ca_system_score_gemma":0.0009338204,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008695389,"about_ca_topic_score_gemma":0.001171988,"domain_scores_codex":[0.9998368,0.00003205514,0.00003289981,0.00002581331,0.00005947407,0.00001291064],"domain_scores_gemma":[0.9995882,0.0002256855,0.00007030103,0.000009548024,0.0000802129,0.00002604663],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007293491,0.00006631458,0.0003162771,0.03614032,0.0001355943,0.0003355934,0.00009457256,0.0002057215,0.001267832,0.001905309,0.01723021,0.9422293],"study_design_scores_gemma":[0.0000229401,0.0001361571,0.002288867,0.01226342,0.0004143453,0.004763517,0.0001304797,0.00007613424,0.0006430199,0.002106693,0.9771321,0.0000222958],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001209101,0.9992024,0.00004588235,0.0001505465,0.00006292035,0.000002318885,0.000009422588,0.000002676167,0.0004029899],"genre_scores_gemma":[0.0005801657,0.9990423,0.0000700052,0.00006712223,0.00006621174,0.000002434489,0.00001332078,4.974851e-7,0.0001578657],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003020506,"threshold_uncertainty_score":0.01010454,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1023241196762151,"score_gpt":0.3798414275477571,"score_spread":0.277517307871542,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}