{"id":"W2123320426","doi":"10.1093/hmg/ddl009","title":"Impaired helix 12 dynamics due to proline 892 substitutions in the androgen receptor are associated with complete androgen insensitivity","year":2006,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"","keywords":"Androgen insensitivity syndrome; Androgen receptor; Ligand (biochemistry); Mutant; Receptor; Docking (animal); Helix (gastropod); Biology; Nuclear receptor; Molecular dynamics; Biophysics; Chemistry; Biochemistry; Genetics; Transcription factor; Medicine; Computational chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003030635,0.0003238852,0.0002878415,0.00009617731,0.0002474744,0.00006196321,0.0002933436,0.000286661,0.000003950724],"category_scores_gemma":[0.00004578162,0.0002612084,0.0001242183,0.0003220733,0.00016458,0.000003810027,0.0001053415,0.0002449333,0.00001279749],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007735733,"about_ca_system_score_gemma":0.0000856884,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008022652,"about_ca_topic_score_gemma":0.002541437,"domain_scores_codex":[0.9980918,0.0003255028,0.0003109189,0.0004919362,0.0002916826,0.0004881928],"domain_scores_gemma":[0.9990305,0.0000185151,0.000142389,0.0005607009,0.0001335211,0.0001143955],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001824078,0.0007050303,0.02008531,0.00002557578,0.0002515558,0.0007321226,0.000158121,0.005117811,0.970638,0.0006438469,0.001142915,0.0003172955],"study_design_scores_gemma":[0.00819145,0.004480677,0.5693212,0.0003778482,0.0005939916,0.001121207,0.0004339534,0.004993152,0.3995952,0.000867504,0.007019823,0.003003999],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957702,0.0009042028,0.001549354,0.0002267123,0.00004406999,0.0008660353,0.0001782342,0.00003159924,0.0004296493],"genre_scores_gemma":[0.9972237,0.00002518883,0.0005153393,0.0003703112,0.00009567872,0.00006412146,0.001572157,0.0000546352,0.00007888649],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5710428,"threshold_uncertainty_score":0.999984,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009570275223593315,"score_gpt":0.223926219005311,"score_spread":0.2143559437817176,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}