{"id":"W2123327333","doi":"10.1002/anie.201403065","title":"Enantioselective Organocatalytic Michael/Aldol Sequence: Anticancer Natural Product (+)‐<i>trans</i>‐Dihydrolycoricidine","year":2014,"lang":"en","type":"article","venue":"Angewandte Chemie International Edition","topic":"Chemical synthesis and alkaloids","field":"Chemistry","cited_by":65,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Stereocenter; Aldol reaction; Enantioselective synthesis; Michael reaction; Natural product; Stereochemistry; Intramolecular force; Chemistry; Cinnamaldehyde; Sequence (biology); Organic chemistry; Catalysis; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002688768,0.0006793205,0.000421522,0.0002396768,0.0002377828,0.000293891,0.0006154654,0.0002839112,0.002186831],"category_scores_gemma":[0.0001831592,0.0002156276,0.0002719018,0.000253739,0.000263286,0.0003750998,0.0003834948,0.0007694139,0.001389094],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005389875,"about_ca_system_score_gemma":0.0007344829,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008145401,"about_ca_topic_score_gemma":0.001272052,"domain_scores_codex":[0.9998254,0.00003093252,0.00001624409,0.00004341103,0.00003488756,0.00004910644],"domain_scores_gemma":[0.99993,0.000008107186,0.00001646192,0.0000107641,0.00001636562,0.00001833135],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000348588,0.0001744627,0.0003718476,0.0005658887,0.00007834308,0.001072226,0.000182377,0.001607472,0.9666187,0.006944918,0.002049866,0.01998532],"study_design_scores_gemma":[0.00009316242,0.0004733635,0.0004477115,0.00001166838,0.00002848719,0.0008107442,0.00002894546,0.00122164,0.9823028,0.0005044066,0.01404934,0.00002765416],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7528756,0.004464308,0.1642276,0.0009980844,0.001361351,0.001241667,0.002520404,0.002132081,0.07017906],"genre_scores_gemma":[0.9604273,0.002561907,0.02633591,0.0001327893,0.00007652373,0.000168959,0.0006439688,0.00009406837,0.009558698],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002186831,"threshold_uncertainty_score":0.007315695,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01020371049110509,"score_gpt":0.2435399760993914,"score_spread":0.2333362656082864,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}