{"id":"W2123352987","doi":"10.1016/j.cgh.2012.12.035","title":"A Test-based Strategy Is More Cost Effective Than Empiric Dose Escalation for Patients With Crohn's Disease Who Lose Responsiveness to Infliximab","year":2013,"lang":"en","type":"article","venue":"Clinical Gastroenterology and Hepatology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":177,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"","keywords":"Medicine; Infliximab; De-escalation; Cost effectiveness; Crohn's disease; Incremental cost-effectiveness ratio; Quality-adjusted life year; Empiric therapy; Disease; Internal medicine; Intensive care medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001416293,0.000761734,0.002073439,0.001307339,0.0003930136,0.001793841,0.0006414675,0.001204784,0.007933909],"category_scores_gemma":[0.007837295,0.0002873862,0.001455119,0.0007097898,0.0003923031,0.001305503,0.0006745099,0.001944628,0.00134811],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007402379,"about_ca_system_score_gemma":0.001123955,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009885083,"about_ca_topic_score_gemma":0.001982168,"domain_scores_codex":[0.9986388,0.00065321,0.0001221637,0.000138866,0.0003362524,0.0001106529],"domain_scores_gemma":[0.9954565,0.002646141,0.0006072895,0.0002981407,0.0003032083,0.000688775],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.01302038,0.007118763,0.05154467,0.0004411531,0.0007565338,0.0008366937,0.0001337837,0.003849835,0.006295505,0.0008385049,0.01194234,0.9032218],"study_design_scores_gemma":[0.02609652,0.09348284,0.7192411,0.001718155,0.005496809,0.01236058,0.001026451,0.04747962,0.01656833,0.01064124,0.06540889,0.0004794169],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8648509,0.02648208,0.0408413,0.03244954,0.001990221,0.001875535,0.0009892927,0.002205479,0.02831563],"genre_scores_gemma":[0.9728592,0.00225179,0.0151361,0.00642219,0.0007297132,0.0002696005,0.0004655108,0.00009810981,0.001767841],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007933909,"threshold_uncertainty_score":0.02654159,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01148184657264841,"score_gpt":0.3027075209630255,"score_spread":0.2912256743903771,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}