{"id":"W2123407640","doi":"10.1016/j.bmc.2008.01.033","title":"The structure-based design, synthesis and biological evaluation of DNA-binding bisintercalating bisanthrapyrazole anticancer compounds","year":2008,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba","funders":"National Cancer Institute","keywords":"Chemistry; DNA; Stereochemistry; Combinatorial chemistry; Chemical synthesis; Biochemistry; Computational biology; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000272097,0.0002727588,0.000237568,0.000214407,0.0002354542,0.0003682992,0.0005320229,0.0003129161,0.001123686],"category_scores_gemma":[0.000307177,0.0002004585,0.0001782504,0.0002020895,0.0002118294,0.0002486489,0.0001651031,0.0005621028,0.0002891771],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006153111,"about_ca_system_score_gemma":0.0003074044,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001159166,"about_ca_topic_score_gemma":0.002148572,"domain_scores_codex":[0.9998708,0.00002352436,0.00001022543,0.00002414208,0.00004231135,0.00002894859],"domain_scores_gemma":[0.9999083,0.00001614264,0.00002363169,0.00001344694,0.00002445349,0.00001398989],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001944578,0.000166373,0.0001235354,0.00006958287,0.000006639888,0.0000411718,0.00003963182,0.001965657,0.9846827,0.0006219448,0.00009178968,0.0119965],"study_design_scores_gemma":[0.00004770619,0.0005121724,0.0002735209,0.000002815056,0.00001241787,0.00007463462,0.00000804395,0.001709532,0.9952019,0.00003666275,0.002115926,0.000004585789],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9866895,0.002389007,0.007265071,0.0001489375,0.00002327174,0.0001495253,0.0001855524,0.0001658086,0.002983426],"genre_scores_gemma":[0.9821365,0.001701224,0.01156931,0.00007054747,0.000009283054,0.00007090063,0.0004828904,0.00002976325,0.003929591],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001159166,"threshold_uncertainty_score":0.004464447,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05639424466243561,"score_gpt":0.2901789059184184,"score_spread":0.2337846612559828,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}