{"id":"W2123415654","doi":"10.1152/ajpregu.90478.2008","title":"Caloric restriction optimizes the proteasome pathway with aging in rat plantaris muscle: implications for sarcopenia","year":2008,"lang":"en","type":"article","venue":"American Journal of Physiology-Regulatory, Integrative and Comparative Physiology","topic":"Muscle metabolism and nutrition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":80,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Sarcopenia; Proteasome; Calorie restriction; Internal medicine; Endocrinology; Skeletal muscle; Senescence; Plantaris muscle; Protein degradation; Calorie; Biology; Chemistry; Biochemistry; Medicine; Soleus muscle","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001836454,0.0002689864,0.0006352856,0.0001272446,0.0002644027,0.000009665056,0.0002466203,0.0000725618,0.000004415891],"category_scores_gemma":[0.00003320428,0.000159315,0.0001265883,0.0002648601,0.001167548,0.00002949675,0.00004857353,0.0002809178,7.310525e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002914558,"about_ca_system_score_gemma":0.0001692339,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007235206,"about_ca_topic_score_gemma":0.00007193516,"domain_scores_codex":[0.9984137,0.000450824,0.0004063877,0.0003712259,0.00008245884,0.0002753469],"domain_scores_gemma":[0.9985825,0.0001618977,0.000577557,0.0002549199,0.000344976,0.00007817248],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001577431,0.0001498549,0.001259194,0.000008678132,0.0001236688,7.332331e-7,0.0006149344,0.000455916,0.992962,0.0007141125,0.0009728366,0.001160635],"study_design_scores_gemma":[0.002529192,0.004576534,0.8437268,0.00006753812,0.0000567509,0.0001210158,0.002654487,0.00009811834,0.1390588,0.001690553,0.005051041,0.0003691472],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964889,0.0009059387,0.001583317,0.0003698461,0.0001023186,0.0004715604,0.00004149002,0.000005146752,0.00003144805],"genre_scores_gemma":[0.9966191,0.0007487668,0.00178968,0.0002344082,0.000334765,0.0001628786,0.00007386095,0.0000137926,0.00002275959],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8539032,"threshold_uncertainty_score":0.6496676,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0226445741549241,"score_gpt":0.2658684208764892,"score_spread":0.2432238467215651,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}