{"id":"W2123438831","doi":"10.1534/g3.111.001933","title":"The Yeast Ubr1 Ubiquitin Ligase Participates in a Prominent Pathway That Targets Cytosolic Thermosensitive Mutants for Degradation","year":2012,"lang":"en","type":"article","venue":"G3 Genes Genomes Genetics","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Ubiquitin ligase; Ubiquitin; Mutant; DNA ligase; Cytosol; Proteasome; Proteolysis; Saccharomyces cerevisiae; Biology; Cell biology; Ubiquitin-Protein Ligases; Protein degradation; Mutation; Biochemistry; Yeast; Gene; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006135295,0.0003157849,0.0002287432,0.00005374872,0.000250559,0.00006224307,0.000274211,0.0001897672,0.00001036485],"category_scores_gemma":[0.00003271273,0.0002501289,0.0001367,0.0001183002,0.0001220334,0.000008842389,0.0001726726,0.00009500745,0.0000214772],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003906349,"about_ca_system_score_gemma":0.0001349187,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008499057,"about_ca_topic_score_gemma":0.0001317458,"domain_scores_codex":[0.9979838,0.0001715074,0.0003661099,0.0004019939,0.0001960242,0.0008806175],"domain_scores_gemma":[0.9989614,0.00005706275,0.0001824707,0.0004860022,0.000121359,0.0001916557],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001453557,0.00009323743,0.01066428,0.00003272827,0.00006007593,0.000002161021,0.0008202136,0.00006524369,0.6338639,0.00006901033,0.00008716572,0.3540966],"study_design_scores_gemma":[0.0005964352,0.0002549856,0.002621563,0.0000149339,0.000027234,0.00001714355,0.0005424371,0.0003178989,0.8907602,0.0001697148,0.104352,0.0003254801],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8132822,0.1840976,0.000670656,0.0001549956,0.0002885012,0.001129992,0.0001730242,0.00001829228,0.0001847726],"genre_scores_gemma":[0.9799535,0.0169243,0.001090685,0.0002157042,0.0006461012,0.0005565521,0.0002379365,0.00006623677,0.0003089276],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3537711,"threshold_uncertainty_score":0.9999951,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03631484636816403,"score_gpt":0.2724055916887806,"score_spread":0.2360907453206166,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}