{"id":"W2123467807","doi":"10.1158/0008-5472.can-08-4287","title":"Akt1 and Akt2 Play Distinct Roles in the Initiation and Metastatic Phases of Mammary Tumor Progression","year":2009,"lang":"en","type":"article","venue":"Cancer Research","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":169,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; McGill University","funders":"National Cancer Institute; U.S. Public Health Service","keywords":"AKT2; AKT1; Mammary tumor; Biology; Protein kinase B; Genetically modified mouse; Cancer research; Tumor progression; Metastasis; Mammary gland; PI3K/AKT/mTOR pathway; Transgene; Mouse mammary tumor virus; Involution (esoterism); Cancer; Pathology; Signal transduction; Immunology; Cell biology; Medicine; Breast cancer; Virus; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001582428,0.0003834778,0.0001468779,0.0002929684,0.000204274,0.0004022662,0.0001289903,0.0001913547,0.0009127576],"category_scores_gemma":[0.00007042001,0.0001669405,0.0001866893,0.0001648063,0.0002388701,0.0002569572,0.0001878628,0.0003431148,0.0003161981],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003677944,"about_ca_system_score_gemma":0.0003731941,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000360653,"about_ca_topic_score_gemma":0.0007668301,"domain_scores_codex":[0.9999133,0.00001188471,0.000005902304,0.0000157153,0.00002315659,0.00002998058],"domain_scores_gemma":[0.9999483,0.000004864153,0.00001566827,0.000004080105,0.000004816216,0.00002238387],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003542083,0.00002992926,0.00120817,0.00002569326,0.000003919876,0.00008361799,0.0000134844,0.0001050622,0.9946746,0.0009493594,0.00005270181,0.002499369],"study_design_scores_gemma":[0.00005418261,0.0003800543,0.03349037,0.000009463092,0.00003200749,0.001295076,0.00005787258,0.001472517,0.9583088,0.0005023494,0.004385292,0.00001204037],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937649,0.002487214,0.001484851,0.000114634,0.00001341364,0.00001392871,0.0002348198,0.00004122705,0.00184511],"genre_scores_gemma":[0.9936025,0.001848162,0.001317532,0.00002818414,0.00001013527,0.00001921364,0.0003668713,0.000009161103,0.002798139],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009127576,"threshold_uncertainty_score":0.003053486,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05633121808714555,"score_gpt":0.4257378210336421,"score_spread":0.3694066029464966,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}