{"id":"W2123473417","doi":"10.1128/cvi.05071-11","title":"Single and Combination Herpes Simplex Virus Type 2 Glycoprotein Vaccines Adjuvanted with CpG Oligodeoxynucleotides or Monophosphoryl Lipid A Exhibit Differential Immunity That Is Not Correlated to Protection in Animal Models","year":2011,"lang":"en","type":"article","venue":"Clinical and Vaccine Immunology","topic":"Herpesvirus Infections and Treatments","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Pfizer (Canada)","funders":"GlaxoSmithKline; Pfizer","keywords":"Virology; Herpes simplex virus; Immunity; CpG Oligodeoxynucleotide; Glycoprotein; Biology; Vector (molecular biology); Antibody; Immunology; Virus; Immune system; Recombinant DNA; Gene; Molecular biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004609538,0.00092911,0.00087989,0.0006247688,0.0001103654,0.0003486116,0.0003210448,0.0005781438,0.001049256],"category_scores_gemma":[0.0001991136,0.0002700303,0.0004724334,0.0002385688,0.000424704,0.0004968293,0.0002211763,0.001217357,0.0004098276],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002056622,"about_ca_system_score_gemma":0.0003247205,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002101967,"about_ca_topic_score_gemma":0.0005418179,"domain_scores_codex":[0.9996476,0.00004876903,0.00002514301,0.00009212187,0.0001129995,0.00007335762],"domain_scores_gemma":[0.999821,0.00004187028,0.00004388336,0.00003195458,0.00001822386,0.00004313043],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009801511,0.0006809437,0.0002593602,0.0001775834,0.00003655768,0.00003781907,0.00001533829,0.0002067368,0.9900187,0.00009037823,0.00009152402,0.007404819],"study_design_scores_gemma":[0.0001725766,0.0253044,0.002263878,0.00001726094,0.0001195321,0.0005004551,0.00002035645,0.0008125145,0.9684994,0.0001292002,0.002147431,0.00001303141],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9853584,0.004748169,0.006953437,0.0001264772,0.0002108072,0.0001802021,0.0003307,0.0001807825,0.001911055],"genre_scores_gemma":[0.9871461,0.003563564,0.005434035,0.0001214303,0.0001012079,0.0001848417,0.0004936897,0.00003799274,0.002917084],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001049256,"threshold_uncertainty_score":0.003510118,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1033520953561621,"score_gpt":0.3147103086766643,"score_spread":0.2113582133205022,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}