{"id":"W2123477611","doi":"10.1158/1078-0432.ccr-07-0780","title":"Irinophore C: A Liposome Formulation of Irinotecan with Substantially Improved Therapeutic Efficacy against a Panel of Human Xenograft Tumors","year":2008,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"","keywords":"Irinotecan; Pharmacokinetics; Pharmacology; Chemistry; Camptothecin; Medicine; Internal medicine; Cancer; Biochemistry; Colorectal cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003549559,0.000544847,0.0003770688,0.0002564662,0.0001106005,0.0003235176,0.0002247397,0.000434371,0.001018974],"category_scores_gemma":[0.0001775514,0.0001209632,0.0002047861,0.0001645574,0.0002795924,0.0004688545,0.0001872778,0.0006222486,0.000297331],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007415401,"about_ca_system_score_gemma":0.0005430096,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001013315,"about_ca_topic_score_gemma":0.001353306,"domain_scores_codex":[0.9998055,0.00003123588,0.0000158881,0.00005938832,0.00005664269,0.00003137458],"domain_scores_gemma":[0.9998779,0.00001604233,0.00003886062,0.00001350745,0.00002286516,0.00003077789],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005345461,0.0001927054,0.0001352175,0.00008483464,0.00001349027,0.00004705962,0.00001172169,0.0002587536,0.9943653,0.00009728622,0.0001314574,0.004127478],"study_design_scores_gemma":[0.0002352046,0.003218199,0.002345224,0.000007869015,0.00004205424,0.0004534749,0.000008199167,0.001198773,0.9890468,0.0000155315,0.003414782,0.00001387793],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906323,0.001955983,0.004644124,0.0002019005,0.00005063762,0.0002630325,0.0004384982,0.0001163036,0.001697226],"genre_scores_gemma":[0.987569,0.001417668,0.007985104,0.0001451861,0.00002683148,0.0001113433,0.0007683764,0.00002807852,0.001948401],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001018974,"threshold_uncertainty_score":0.005380273,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2222694447999352,"score_gpt":0.4494059536909869,"score_spread":0.2271365088910517,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}