{"id":"W2123497942","doi":"10.1038/nm.2278","title":"Histamine deficiency promotes inflammation-associated carcinogenesis through reduced myeloid maturation and accumulation of CD11b+Ly6G+ immature myeloid cells","year":2010,"lang":"en","type":"article","venue":"Nature Medicine","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":245,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute; Canadian Institutes of Health Research","keywords":"Myeloid; Carcinogenesis; Biology; Cancer research; Histamine; Immunology; Cancer; Endocrinology; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001256264,0.0002723228,0.0003123331,0.0002890542,0.0001210074,0.0003149825,0.0001649827,0.0003193259,0.001533094],"category_scores_gemma":[0.0001369405,0.0001867363,0.0001778714,0.0001151591,0.000327066,0.0002234023,0.0001750173,0.0007097563,0.0002467979],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003257363,"about_ca_system_score_gemma":0.0001815967,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004724949,"about_ca_topic_score_gemma":0.0007436047,"domain_scores_codex":[0.999819,0.00003326348,0.0000129016,0.00003683456,0.0000438182,0.00005415983],"domain_scores_gemma":[0.9997874,0.00001789268,0.00008587142,0.00002007255,0.00001265187,0.00007619331],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006682212,0.00002734635,0.0004030858,0.00001543608,0.000004305774,0.00008198839,0.00000396144,0.0000177729,0.9978412,0.00005228929,0.00002998784,0.0008543688],"study_design_scores_gemma":[0.0001569804,0.001296516,0.04723613,0.000008794964,0.00005299916,0.001295259,0.00006201982,0.0008716652,0.9467136,0.0002069018,0.002089635,0.00000936385],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972792,0.0008551426,0.001033989,0.0001042019,0.00002030929,0.00001343896,0.0001528719,0.00006741758,0.0004733625],"genre_scores_gemma":[0.9978072,0.0003474975,0.0005439247,0.00002449379,0.00001226124,0.0000105383,0.00008840729,0.00001330777,0.001152313],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001533094,"threshold_uncertainty_score":0.005128682,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01365790800778793,"score_gpt":0.2716078657585232,"score_spread":0.2579499577507353,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}