{"id":"W2123500323","doi":"10.1176/appi.ajp.2009.09010017","title":"The Cognitive Cost of Anticholinergic Burden: Decreased Response to Cognitive Training in Schizophrenia","year":2009,"lang":"en","type":"article","venue":"American Journal of Psychiatry","topic":"Schizophrenia research and treatment","field":"Medicine","cited_by":216,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health","funders":"National Center for Research Resources; National Institutes of Health; National Institute of Mental Health; H. Lundbeck A/S","keywords":"Anticholinergic; Neurocognitive; Cognition; Schizophrenia (object-oriented programming); Cognitive training; Effects of sleep deprivation on cognitive performance; Cognitive remediation therapy; Psychology; Verbal memory; Verbal learning; Working memory; Anticholinergic agents; Clinical psychology; Psychiatry; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002819537,0.0002759042,0.0002825923,0.0002011668,0.0001622505,0.0001831001,0.0001266551,0.0002313745,0.001091099],"category_scores_gemma":[0.001506969,0.00007602378,0.0002595178,0.000195695,0.0001628848,0.000133517,0.0001823993,0.0002615472,0.00009273656],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002656767,"about_ca_system_score_gemma":0.0002661592,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001688169,"about_ca_topic_score_gemma":0.00268315,"domain_scores_codex":[0.9998511,0.00004225729,0.00002213362,0.00001542361,0.00004408359,0.00002488572],"domain_scores_gemma":[0.9994023,0.0001330029,0.000286999,0.00002359458,0.00004355975,0.0001105525],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01838142,0.002713218,0.8720033,0.0002060726,0.0004516614,0.000363413,0.0001958705,0.0007573686,0.01699744,0.0000351139,0.0002337553,0.08766137],"study_design_scores_gemma":[0.0001304418,0.002555753,0.9963406,0.000006791726,0.00004669508,0.0001341853,0.00003495163,0.0002123247,0.0004611778,0.00001868234,0.00005558335,0.000002875077],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99962,0.0001401471,0.00002136276,0.00002256289,0.000001804639,0.000005139821,0.00002462857,0.00000209277,0.0001622684],"genre_scores_gemma":[0.9997647,0.00006830362,0.00004628124,0.00001499404,0.000003746249,0.000004056165,0.00003951097,3.483996e-7,0.00005802173],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001688169,"threshold_uncertainty_score":0.003650069,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01720171300084256,"score_gpt":0.3322211557413097,"score_spread":0.3150194427404672,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}