{"id":"W2123500518","doi":"10.1002/anie.201503182","title":"Biosensing by Tandem Reactions of Structure Switching, Nucleolytic Digestion, and DNA Amplification of a DNA Assembly","year":2015,"lang":"en","type":"article","venue":"Angewandte Chemie International Edition","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":67,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Rolling circle replication; Primer (cosmetics); DNA; Aptamer; DNA polymerase; Amplicon; Multiple displacement amplification; DNA clamp; Biology; Molecular biology; Chemistry; Computational biology; Polymerase chain reaction; Genetics; Reverse transcriptase; DNA extraction; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004725442,0.0006988219,0.0005169419,0.0003704498,0.000151061,0.0004747072,0.0007281032,0.0004461963,0.0004106211],"category_scores_gemma":[0.0005357586,0.000665657,0.0003200568,0.0003218437,0.0003992997,0.0004455152,0.0005325117,0.0007771375,0.0005285529],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003832953,"about_ca_system_score_gemma":0.0002900773,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000161221,"about_ca_topic_score_gemma":0.0002688286,"domain_scores_codex":[0.999317,0.00008191686,0.00004881488,0.0002209757,0.0002637046,0.00006749192],"domain_scores_gemma":[0.9997304,0.00008996238,0.00007669979,0.00003207646,0.0000394572,0.00003129238],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003016237,0.00001620759,0.00006328521,0.00004233959,0.000005338027,0.00003369917,0.0000187259,0.0001633939,0.9926677,0.0003460702,0.00004525901,0.006567762],"study_design_scores_gemma":[0.00000360917,0.0000549312,0.00008984079,0.000001857329,0.000003936656,0.00007694009,0.000003165679,0.001510184,0.9970824,0.0000561825,0.00111307,0.000003911557],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5588648,0.006308604,0.4237899,0.0002609391,0.000254715,0.0003035818,0.0001592476,0.002414823,0.00764337],"genre_scores_gemma":[0.794661,0.001809493,0.1978162,0.0001317642,0.00005222518,0.0002293346,0.0002160726,0.00006253416,0.005021542],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007281032,"threshold_uncertainty_score":0.002781093,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01299408499063175,"score_gpt":0.2732007975136005,"score_spread":0.2602067125229688,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}