{"id":"W2123518388","doi":"10.1086/517499","title":"A Simple Screening Approach to Reduce B*5701-Associated Abacavir Hypersensitivity on the Basis of Sequence Variation in HIV Reverse Transcriptase","year":2007,"lang":"en","type":"article","venue":"Clinical Infectious Diseases","topic":"Drug-Induced Adverse Reactions","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"AIDS Vancouver; University of British Columbia","funders":"","keywords":"Abacavir; Medicine; Human leukocyte antigen; Reverse transcriptase; Discontinuation; HLA-B; Virology; Immunology; Viral load; Internal medicine; Virus; Biology; Antigen; Genetics; Polymerase chain reaction; Antiretroviral therapy; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005635985,0.0006327502,0.0008197278,0.0008925378,0.0001924713,0.0003919895,0.0005369088,0.0004508486,0.002272559],"category_scores_gemma":[0.001194068,0.0002040112,0.0004160697,0.0003593983,0.0002578638,0.0001912738,0.0003814452,0.0005505353,0.0004907458],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001920253,"about_ca_system_score_gemma":0.0003916968,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006359505,"about_ca_topic_score_gemma":0.001260992,"domain_scores_codex":[0.9995746,0.0001201471,0.00003559245,0.0001040107,0.0001212506,0.00004427808],"domain_scores_gemma":[0.9994127,0.0001951522,0.0001607015,0.00005641938,0.00008468001,0.00009041157],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.004053083,0.004325782,0.1483338,0.0005351389,0.0003199614,0.0006397907,0.000188322,0.001556676,0.3375432,0.0004263156,0.00466941,0.4974085],"study_design_scores_gemma":[0.002165149,0.02456778,0.6837429,0.0001795258,0.001024257,0.008863787,0.0002490417,0.02393201,0.2358595,0.001327052,0.01789341,0.0001956233],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9472133,0.002442664,0.04491839,0.0006307883,0.0001666067,0.001409862,0.0004155751,0.0005293126,0.002273605],"genre_scores_gemma":[0.9265172,0.0008730633,0.06915888,0.0008000768,0.0001304204,0.0003730068,0.0006178583,0.00003807709,0.001491424],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002272559,"threshold_uncertainty_score":0.007602453,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1058429310115048,"score_gpt":0.3800430003619351,"score_spread":0.2742000693504303,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}