{"id":"W2123527017","doi":"10.1126/scisignal.2000316","title":"Comparative Analysis Reveals Conserved Protein Phosphorylation Networks Implicated in Multiple Diseases","year":2009,"lang":"en","type":"article","venue":"Science Signaling","topic":"Bioinformatics and Genomic Networks","field":"Biochemistry, Genetics and Molecular Biology","cited_by":206,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"","keywords":"Phosphorylation; Biology; Computational biology; Cell biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001789913,0.0002339466,0.0001921918,0.001407021,0.0002159809,0.0001962298,0.0001585579,0.0001671219,0.0008037887],"category_scores_gemma":[0.0004428853,0.00008331573,0.0002094227,0.0008705798,0.0001492872,0.0002562108,0.0002332648,0.0001517626,0.0001354959],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002535893,"about_ca_system_score_gemma":0.0001462011,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005043768,"about_ca_topic_score_gemma":0.0009021398,"domain_scores_codex":[0.9999006,0.00002271862,0.000007169157,0.0000334645,0.0000216642,0.00001443419],"domain_scores_gemma":[0.999798,0.00006151099,0.00008460577,0.00001406135,0.00001438499,0.00002743653],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.002470428,0.0002103965,0.2015507,0.0006894695,0.0006285437,0.002739023,0.0003481398,0.0169839,0.6949975,0.004130561,0.0007524097,0.07449892],"study_design_scores_gemma":[0.00006016868,0.0003742461,0.84575,0.00004019398,0.0005027447,0.004148887,0.0002410147,0.07164779,0.06679337,0.00605501,0.004357037,0.00002953732],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951434,0.0004923735,0.003337599,0.00003686918,0.000002292017,0.000007441186,0.0004872367,0.00004245487,0.0004503537],"genre_scores_gemma":[0.9946758,0.0002798045,0.003947668,0.000009410167,0.00000332754,0.000007961346,0.0009442958,0.000006191541,0.0001256842],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001407021,"threshold_uncertainty_score":0.002688944,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01674279931077154,"score_gpt":0.2676756110726967,"score_spread":0.2509328117619251,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}