{"id":"W2123527017","doi":"10.1126/scisignal.2000316","title":"Comparative Analysis Reveals Conserved Protein Phosphorylation Networks Implicated in Multiple Diseases","year":2009,"lang":"en","type":"article","venue":"Science Signaling","topic":"Bioinformatics and Genomic Networks","field":"Biochemistry, Genetics and Molecular Biology","cited_by":206,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"","keywords":"Phosphorylation; Biology; Computational biology; Cell biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004709132,0.0001147741,0.0001908638,0.0001239815,0.0001729084,0.00007307273,0.0002455707,0.00006815675,0.0000085759],"category_scores_gemma":[0.00004501838,0.0001060411,0.00007499019,0.001100708,0.0001700725,0.0000142001,0.00004570016,0.00008074989,0.000002325867],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002733338,"about_ca_system_score_gemma":0.00008057743,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002081974,"about_ca_topic_score_gemma":0.00003236597,"domain_scores_codex":[0.998925,0.00003404891,0.0002866865,0.0003038599,0.0001388699,0.0003115797],"domain_scores_gemma":[0.9994157,0.00001412437,0.0001310777,0.0002385562,0.00009930704,0.0001012303],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.00006422801,0.00004692616,0.01535911,0.000002634229,0.0000343211,8.409198e-7,0.000121871,0.1235264,0.8592786,0.0001465564,0.0000601781,0.001358336],"study_design_scores_gemma":[0.0008491403,0.0002483771,0.153898,0.00004733998,0.00008955287,0.000001715068,0.0002876152,0.6267253,0.2157972,0.001442713,0.0001147656,0.0004983258],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9741778,0.0004385243,0.02474814,0.00005999018,0.00002520173,0.00030564,0.000007358749,0.00001117695,0.0002261675],"genre_scores_gemma":[0.998444,0.00000782989,0.001179311,0.0001951629,0.00004467099,0.00001334209,0.00008427376,0.000002631841,0.00002884167],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6434814,"threshold_uncertainty_score":0.4324232,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01674279931077154,"score_gpt":0.2676756110726967,"score_spread":0.2509328117619251,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}