{"id":"W2123562881","doi":"10.1242/jcs.078949","title":"Phosphorylation controls a dual-function polybasic nuclear localization sequence in the adapter protein SH2B1β to regulate its cellular function and distribution","year":2011,"lang":"en","type":"article","venue":"Journal of Cell Science","topic":"Skin and Cellular Biology Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of General Medical Sciences","keywords":"NLS; Cell biology; Nuclear localization sequence; Biology; Phosphorylation; Neurite; Nuclear transport; Activator (genetics); Signal transducing adaptor protein; Dephosphorylation; Cell nucleus; Nucleus; Gene; Biochemistry; Phosphatase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001373836,0.0003074821,0.0001243366,0.0001319654,0.0001998695,0.0002788351,0.0001644104,0.0001928276,0.002017735],"category_scores_gemma":[0.00009649351,0.0001221902,0.0001899136,0.00009911189,0.0002197375,0.0002536338,0.0003233455,0.0004101533,0.0008027534],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002620661,"about_ca_system_score_gemma":0.0001202165,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002689145,"about_ca_topic_score_gemma":0.0005648257,"domain_scores_codex":[0.9998919,0.0000182909,0.000007118515,0.0000328039,0.0000202726,0.00002954206],"domain_scores_gemma":[0.9999163,0.000008733654,0.00003076434,0.000008669606,0.000008957922,0.00002658025],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008533806,0.00001134968,0.0003490858,0.00002076329,0.000002792082,0.00004796084,0.00001133292,0.00002656405,0.9982867,0.0001380949,0.00002626434,0.000993866],"study_design_scores_gemma":[0.00006188815,0.0002604559,0.03279185,0.00001922383,0.00001721349,0.0008967851,0.0001025878,0.002422309,0.9577859,0.0004433079,0.005187473,0.00001101341],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919245,0.00211028,0.003728807,0.00009853639,0.00003443917,0.00001816379,0.0001029962,0.0000439379,0.001938467],"genre_scores_gemma":[0.9965783,0.0005373937,0.001283505,0.00003751977,0.000008729263,0.00001426244,0.0001605301,0.00001079246,0.00136906],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002017735,"threshold_uncertainty_score":0.006749988,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01963570650687809,"score_gpt":0.2369642775310885,"score_spread":0.2173285710242104,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}