{"id":"W2123611729","doi":"10.1158/0008-5472.can-08-2223","title":"Genetic Predictors of MEK Dependence in Non–Small Cell Lung Cancer","year":2008,"lang":"en","type":"article","venue":"Cancer Research","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":254,"is_retracted":false,"has_abstract":true,"ca_institutions":"Immunovaccine (Canada)","funders":"U.S. Public Health Service; Chung Shan Medical University; National Cancer Institute; National Institutes of Health; Chiba University; Samuel Waxman Cancer Research Foundation","keywords":"KRAS; Cancer research; MAPK/ERK pathway; Lung cancer; Epidermal growth factor receptor; Kinase; MEK inhibitor; V600E; Tyrosine kinase; Biology; Receptor tyrosine kinase; Protein kinase domain; Cancer; Mutant; Medicine; Signal transduction; Internal medicine; Colorectal cancer; Cell biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002173974,0.0001632961,0.0001708495,0.0005968647,0.0002139122,0.0002793063,0.0001875698,0.0003047446,0.001273844],"category_scores_gemma":[0.0008996611,0.0001044603,0.0001734062,0.0003501199,0.0002150355,0.0001190338,0.0001658435,0.00027347,0.0002647202],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001558798,"about_ca_system_score_gemma":0.0001596576,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001333339,"about_ca_topic_score_gemma":0.002198585,"domain_scores_codex":[0.9998351,0.00003340587,0.00002260712,0.00003512808,0.00004795385,0.00002569797],"domain_scores_gemma":[0.9991543,0.000276666,0.0002130358,0.00005712037,0.000114299,0.0001845112],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005433042,0.00005358509,0.9613718,0.00001323499,0.00003709381,0.00066986,0.00003446031,0.0001744356,0.03404101,0.00005868369,0.00009283685,0.002909678],"study_design_scores_gemma":[0.000005452446,0.0001374108,0.9924579,0.000001861,0.00002302059,0.002209789,0.00004415186,0.000558987,0.004210273,0.00006187644,0.0002853812,0.000004053212],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991294,0.0001642352,0.0001222169,0.00001674517,0.000003216701,0.000006155711,0.0001333481,0.000005541284,0.0004191214],"genre_scores_gemma":[0.9996898,0.00003509883,0.00006128669,0.000005757674,0.000002199419,0.000002586196,0.00012106,0.000002141439,0.00008005735],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001333339,"threshold_uncertainty_score":0.004261434,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05397553162527113,"score_gpt":0.4196293516469179,"score_spread":0.3656538200216468,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}