{"id":"W2123625165","doi":"10.1128/aac.01572-08","title":"High-Throughput Screening Identifies Novel Inhibitors of the Acetyltransferase Activity of <i>Escherichia coli</i> GlmU","year":2009,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Carbohydrate Chemistry and Synthesis","field":"Chemistry","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"National Institute of Allergy and Infectious Diseases","keywords":"Acetyltransferase; Biochemistry; Peptidoglycan; Escherichia coli; High-throughput screening; Phosphofructokinase 2; Chemistry; Acetyltransferases; Drug discovery; Teichoic acid; Active site; Enzyme; Acetylation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000925844,0.0002409315,0.0003909227,0.0000202281,0.0001371617,0.00003305984,0.0002569879,0.0001673165,0.0001967894],"category_scores_gemma":[0.00001272953,0.0001935301,0.000224309,0.0001777259,0.0002329681,0.0001160311,0.00003672183,0.0001713618,4.327684e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001478997,"about_ca_system_score_gemma":0.00003056303,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001802745,"about_ca_topic_score_gemma":0.00000641088,"domain_scores_codex":[0.9989223,0.00001443606,0.0003430431,0.000299197,0.0001914935,0.0002295581],"domain_scores_gemma":[0.9992798,0.00004068637,0.0002122218,0.0003558544,0.00005707533,0.00005435033],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001740821,0.0003283569,0.001343557,0.0001406649,0.00009450889,9.520294e-7,0.0003783045,0.00001500015,0.9931415,0.00001760483,0.001186934,0.003178563],"study_design_scores_gemma":[0.001152107,0.00001592161,0.005323065,0.0001886107,0.00004975046,0.000003819889,0.00006352857,0.00002645359,0.9917262,0.0000277892,0.00122528,0.0001974962],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975094,0.00002066094,0.0001556714,0.001444628,0.00008032485,0.00008566041,0.0001124472,0.00002506806,0.0005661274],"genre_scores_gemma":[0.9980649,0.0002743993,0.0002810588,0.0008923289,0.0001083623,0.000001737477,0.00000847,0.00002138476,0.0003473538],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003979507,"threshold_uncertainty_score":0.7891927,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01201915415855692,"score_gpt":0.2219868140900868,"score_spread":0.2099676599315299,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}