{"id":"W2123647733","doi":"10.1016/j.cell.2012.02.013","title":"Histone Recognition and Large-Scale Structural Analysis of the Human Bromodomain Family","year":2012,"lang":"en","type":"article","venue":"Cell","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1752,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada Research Chairs; Ontario Institute for Cancer Research; University of Toronto; Lunenfeld-Tanenbaum Research Institute; Structural Genomics Consortium","funders":"Canada Research Chairs; Canadian Institutes of Health Research; Genome Canada; Wellcome Trust; GlaxoSmithKline; Ontario Ministry of Research and Innovation; Natural Sciences and Engineering Research Council of Canada; Pfizer; Eli Lilly and Company","keywords":"Bromodomain; Acetylation; Biology; BRD4; Histone; Computational biology; Genetics; Structural similarity; BET inhibitor; Epigenetics; Biochemistry; DNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001735996,0.0002557361,0.0002170604,0.000186965,0.0001544511,0.0001775505,0.0002386441,0.0001415158,0.0006506472],"category_scores_gemma":[0.0001690778,0.0001213035,0.0003002368,0.0002020755,0.0001270755,0.0001196335,0.0001767226,0.000357225,0.0001782351],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003429179,"about_ca_system_score_gemma":0.0002537852,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009214929,"about_ca_topic_score_gemma":0.001903463,"domain_scores_codex":[0.9999213,0.0000126257,0.000004603064,0.00001528342,0.00003304331,0.00001313987],"domain_scores_gemma":[0.9999402,0.00001066997,0.00001250925,0.000007431479,0.00001105592,0.00001809676],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001575347,0.00006012129,0.001351807,0.00006524443,0.00002407551,0.0001117515,0.00002390636,0.0006491812,0.9926867,0.0001866538,0.0001737808,0.004509293],"study_design_scores_gemma":[0.00005152964,0.0002780305,0.02236251,0.000007011778,0.00006183251,0.0006925411,0.00004838104,0.007627374,0.962418,0.0001911559,0.006247128,0.00001462978],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916732,0.001609699,0.004943252,0.0001351027,0.00001394325,0.00002281037,0.0005743051,0.00005436801,0.0009733774],"genre_scores_gemma":[0.9848275,0.00124117,0.01002854,0.00008068855,0.000007087883,0.00001731831,0.002821309,0.00001885252,0.0009576791],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009214929,"threshold_uncertainty_score":0.002488077,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01339970949480928,"score_gpt":0.2479835714959281,"score_spread":0.2345838620011188,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}