{"id":"W2123679910","doi":"10.1073/pnas.0509736102","title":"Increase in TNF-α and inducible nitric oxide synthase-expressing dendritic cells in psoriasis and reduction with efalizumab (anti-CD11a)","year":2005,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":450,"is_retracted":false,"has_abstract":true,"ca_institutions":"Probity Medical Research","funders":"National Center for Research Resources; National Institute of Allergy and Infectious Diseases; National Institutes of Health","keywords":"CD11c; Psoriasis; Dendritic cell; Nitric oxide synthase; Immunology; CD40; Tumor necrosis factor alpha; Inflammation; CD86; Proinflammatory cytokine; Dermis; Biology; Nitric oxide; Chemistry; Medicine; T cell; Pathology; Immune system; Cytotoxic T cell; Endocrinology; Biochemistry; Phenotype; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009984637,0.00009364764,0.0001781838,0.0004195143,0.0001542852,0.00001885479,0.0002169603,0.0001203258,0.000009545768],"category_scores_gemma":[0.0001935758,0.0000649335,0.00001913898,0.0005804818,0.0009264582,0.0005308774,0.00006326292,0.0002173804,8.399022e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003239986,"about_ca_system_score_gemma":0.00003921004,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006659153,"about_ca_topic_score_gemma":3.603888e-7,"domain_scores_codex":[0.9991841,0.00003388813,0.0002767196,0.0002163654,0.0001259939,0.0001628728],"domain_scores_gemma":[0.9995581,0.0001552155,0.0002061472,0.000009384755,0.00006238673,0.000008802608],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001978504,0.00006938945,0.005033335,0.00002935396,0.00001242109,1.527063e-8,0.0002757134,0.00002749918,0.9917163,0.0008359247,0.00003304641,0.001769211],"study_design_scores_gemma":[0.0007976094,0.00004308749,0.1417597,0.0002421476,0.000009009475,0.00007328325,0.0005678491,0.0000296348,0.8555036,0.0007707449,0.000126334,0.00007699413],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959514,0.002947101,2.260899e-7,0.0006271886,0.00001175575,0.0001374472,0.000004156986,0.000005491622,0.00031519],"genre_scores_gemma":[0.9990683,0.0003517401,0.000395781,0.0000658073,0.00001089338,0.000008670673,1.443392e-7,0.000003740081,0.00009493953],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1367264,"threshold_uncertainty_score":0.3413574,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02045728594947143,"score_gpt":0.266094527432753,"score_spread":0.2456372414832815,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}