{"id":"W2123679910","doi":"10.1073/pnas.0509736102","title":"Increase in TNF-α and inducible nitric oxide synthase-expressing dendritic cells in psoriasis and reduction with efalizumab (anti-CD11a)","year":2005,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":450,"is_retracted":false,"has_abstract":true,"ca_institutions":"Probity Medical Research","funders":"National Center for Research Resources; National Institute of Allergy and Infectious Diseases; National Institutes of Health","keywords":"CD11c; Psoriasis; Dendritic cell; Nitric oxide synthase; Immunology; CD40; Tumor necrosis factor alpha; Inflammation; CD86; Proinflammatory cytokine; Dermis; Biology; Nitric oxide; Chemistry; Medicine; T cell; Pathology; Immune system; Cytotoxic T cell; Endocrinology; Biochemistry; Phenotype; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001329199,0.0001994148,0.0002681337,0.0002080346,0.0001595738,0.0002012974,0.00007217287,0.0002378132,0.001246721],"category_scores_gemma":[0.0001467715,0.0001031672,0.0001243945,0.0001143686,0.0001236542,0.00009312799,0.00008444305,0.0005139158,0.0003376653],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001702481,"about_ca_system_score_gemma":0.00007825619,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000310607,"about_ca_topic_score_gemma":0.0003483417,"domain_scores_codex":[0.9998649,0.00003190394,0.00001196028,0.00001937971,0.00003542339,0.00003645814],"domain_scores_gemma":[0.9999179,0.000008957354,0.00001567636,0.000008810111,0.00001131388,0.00003724661],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005644069,0.0001459002,0.0009078447,0.00002535986,0.000006386377,0.0001348823,0.00001693258,0.00004848467,0.9921293,0.00005994255,0.00009350906,0.005867087],"study_design_scores_gemma":[0.0003892439,0.003320297,0.06819218,0.00001808852,0.00008462962,0.004435024,0.00007541772,0.002110392,0.9126975,0.0001539471,0.008514727,0.000008441492],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941968,0.002428754,0.001133583,0.000126752,0.00004004242,0.00002800188,0.00009656137,0.0001134892,0.001836037],"genre_scores_gemma":[0.9955178,0.0009047316,0.001096831,0.00007947577,0.00002265349,0.00002974685,0.0001751205,0.00001325387,0.002160336],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001246721,"threshold_uncertainty_score":0.004170716,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02045728594947143,"score_gpt":0.266094527432753,"score_spread":0.2456372414832815,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}