{"id":"W2123739134","doi":"10.2174/138920208785699580","title":"Cause and Consequences of Genetic and Epigenetic Alterations in Human Cancer","year":2008,"lang":"en","type":"article","venue":"Current Genomics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":295,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Princess Margaret Cancer Centre; Hospital for Sick Children","funders":"Hospital for Sick Children","keywords":"Epigenetics; Biology; DNA methylation; Genome instability; Genetics; Cancer; Gene; Epigenetic regulation of neurogenesis; Cancer epigenetics; Regulation of gene expression; Computational biology; Gene expression; DNA; DNA damage","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002821645,0.0001299161,0.0002956458,0.0005263812,0.0002067443,0.000402839,0.0002318889,0.0004958509,0.001316006],"category_scores_gemma":[0.000422849,0.00009783763,0.0001871123,0.0007651683,0.0004425921,0.000297649,0.0002991457,0.0003208732,0.0002851569],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004175643,"about_ca_system_score_gemma":0.0003615175,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007473903,"about_ca_topic_score_gemma":0.0006919483,"domain_scores_codex":[0.9997342,0.00005890679,0.0000184539,0.00005809228,0.00009936763,0.00003095213],"domain_scores_gemma":[0.9998952,0.00002638565,0.00004267944,0.000008336524,0.00001491489,0.00001244973],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0007028922,0.0001722762,0.0954895,0.003156583,0.0002456725,0.006173009,0.0006993354,0.002409609,0.3671438,0.03114012,0.005326439,0.4873408],"study_design_scores_gemma":[0.00004480748,0.0009537639,0.5108122,0.0004089274,0.0005779216,0.03125992,0.001045423,0.001952814,0.1380111,0.03329295,0.2815397,0.0001006141],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.4053929,0.5453625,0.01040869,0.005745132,0.0005182299,0.00008293545,0.001211655,0.0002240022,0.03105391],"genre_scores_gemma":[0.8395106,0.1533992,0.002320865,0.0005330096,0.0002613941,0.00002294463,0.000362394,0.00001280574,0.003576786],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001316006,"threshold_uncertainty_score":0.004402518,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04257113057340076,"score_gpt":0.3166533549846646,"score_spread":0.2740822244112638,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}