{"id":"W2123739134","doi":"10.2174/138920208785699580","title":"Cause and Consequences of Genetic and Epigenetic Alterations in Human Cancer","year":2008,"lang":"en","type":"article","venue":"Current Genomics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":295,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Princess Margaret Cancer Centre; Hospital for Sick Children","funders":"Hospital for Sick Children","keywords":"Epigenetics; Biology; DNA methylation; Genome instability; Genetics; Cancer; Gene; Epigenetic regulation of neurogenesis; Cancer epigenetics; Regulation of gene expression; Computational biology; Gene expression; DNA; DNA damage","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005484451,0.00008384242,0.0001025885,0.00004655613,0.00006539578,0.000007281308,0.0000474026,0.00004991636,0.000004035603],"category_scores_gemma":[0.00001416955,0.00008798602,0.00001649877,0.00004009992,0.0002060624,0.000001900497,0.00004554052,0.00004224202,2.355634e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009246173,"about_ca_system_score_gemma":0.00006951541,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006816364,"about_ca_topic_score_gemma":0.0001915476,"domain_scores_codex":[0.9994193,0.00003100699,0.0002045759,0.0001957672,0.00004369862,0.0001056098],"domain_scores_gemma":[0.9997212,0.000007620754,0.00006697119,0.000119905,0.00003683644,0.00004750501],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000006247589,0.00002546231,0.2045849,0.00002229043,0.000009647173,9.394308e-7,0.000235838,0.0003837638,0.7908733,0.00005623518,0.00001201209,0.003789331],"study_design_scores_gemma":[0.000642562,0.0001729476,0.4288756,0.00002937017,0.00002710957,0.00001031486,0.00004129876,0.0002473273,0.5653315,0.0007423862,0.003632687,0.0002468751],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9608839,0.03841932,0.0004102517,0.00002725775,0.00007638316,0.0001236208,0.00002169601,0.00000167976,0.00003589952],"genre_scores_gemma":[0.9673411,0.03209179,0.0004279778,0.000009381887,0.00006027121,0.00001465238,0.0000236395,0.000008050411,0.00002312291],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2255418,"threshold_uncertainty_score":0.3587965,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04257113057340076,"score_gpt":0.3166533549846646,"score_spread":0.2740822244112638,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}