{"id":"W2123753762","doi":"10.2215/cjn.02210310","title":"Relative Role of Genetic Complement Abnormalities in Sporadic and Familial aHUS and Their Impact on Clinical Phenotype","year":2010,"lang":"en","type":"article","venue":"Clinical Journal of the American Society of Nephrology","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":1034,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Fondazione Telethon; Fondazione ART per la Ricerca sui Trapianti","keywords":"Atypical hemolytic uremic syndrome; Medicine; Eculizumab; Factor H; Microangiopathic hemolytic anemia; CD46; Immunology; Complement factor I; Autoantibody; Transplantation; Thrombotic microangiopathy; Complement system; Disease; Internal medicine; Antibody; Thrombotic thrombocytopenic purpura","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["sts"],"consensus_categories":[],"category_scores_codex":[0.001623286,0.0001773963,0.001111487,0.00004940543,0.00006015829,0.000003378351,0.0003757705,0.0001507296,0.00008146215],"category_scores_gemma":[0.0002072807,0.0001038379,0.0006242688,0.0001065224,0.0042681,0.00004061155,0.000220409,0.0008892226,0.000001732645],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001706983,"about_ca_system_score_gemma":0.0001523859,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002135391,"about_ca_topic_score_gemma":0.00004462068,"domain_scores_codex":[0.9967118,0.001133659,0.001653305,0.0001954883,0.00006431268,0.0002414549],"domain_scores_gemma":[0.9945588,0.002980337,0.001982262,0.0002952595,0.0001234056,0.00005994081],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001745201,0.0004633374,0.960188,0.00001399671,0.000878653,0.000001367165,0.0009076818,0.000009139059,0.01987654,0.0002011191,0.004109852,0.01160514],"study_design_scores_gemma":[0.002196769,0.003792549,0.9854781,0.00003875654,0.00009952416,0.00007001153,0.002370871,0.00002906797,0.0001432553,0.001937184,0.003756158,0.00008773377],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972503,0.001165281,0.00001790419,0.0009390169,0.0003486217,0.000185144,0.00006253131,0.000003440662,0.00002779708],"genre_scores_gemma":[0.997167,0.0006181427,0.0004218512,0.001653183,0.000118433,0.000001563622,0.000002224173,0.000009693378,0.000007909077],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02529014,"threshold_uncertainty_score":0.9984417,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03242891993996268,"score_gpt":0.352583384939003,"score_spread":0.3201544649990403,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}