{"id":"W2123753762","doi":"10.2215/cjn.02210310","title":"Relative Role of Genetic Complement Abnormalities in Sporadic and Familial aHUS and Their Impact on Clinical Phenotype","year":2010,"lang":"en","type":"article","venue":"Clinical Journal of the American Society of Nephrology","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":1034,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Fondazione Telethon; Fondazione ART per la Ricerca sui Trapianti","keywords":"Atypical hemolytic uremic syndrome; Medicine; Eculizumab; Factor H; Microangiopathic hemolytic anemia; CD46; Immunology; Complement factor I; Autoantibody; Transplantation; Thrombotic microangiopathy; Complement system; Disease; Internal medicine; Antibody; Thrombotic thrombocytopenic purpura","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009590883,0.0004344114,0.0003681951,0.001576423,0.0004072888,0.0004793902,0.0003498384,0.0007341859,0.003675923],"category_scores_gemma":[0.008064783,0.0001717891,0.0003255367,0.0007042291,0.0006655536,0.0004257253,0.0003946093,0.0003588057,0.0003483332],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001978602,"about_ca_system_score_gemma":0.0002023431,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006452592,"about_ca_topic_score_gemma":0.0004222214,"domain_scores_codex":[0.9990177,0.0003622777,0.000109173,0.0002043534,0.0001677814,0.0001386694],"domain_scores_gemma":[0.9941707,0.00358643,0.001082994,0.0002210853,0.000326627,0.0006120711],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006269359,0.00003644523,0.9908488,0.00001437077,0.0000781904,0.001865503,0.00007015496,0.0001419539,0.001087875,0.00005259808,0.00009597664,0.005081126],"study_design_scores_gemma":[0.00002375643,0.0002033613,0.9865023,0.0000154532,0.00008652298,0.01182123,0.0001565701,0.0005671408,0.0002692184,0.000169978,0.0001749246,0.000009577855],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987863,0.0005946217,0.00008696559,0.00003859568,0.000005486794,0.000002485456,0.00004297889,0.000005421459,0.0004371501],"genre_scores_gemma":[0.9997471,0.00007448359,0.00004626123,0.000008511563,0.00001994915,0.000001491712,0.00006237876,0.000002427709,0.00003738832],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003675923,"threshold_uncertainty_score":0.01229721,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03242891993996268,"score_gpt":0.352583384939003,"score_spread":0.3201544649990403,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}