{"id":"W2123762312","doi":"10.1002/cpdd.35","title":"Pharmacokinetics of Irinotecan With and Without Panitumumab Coadministration in Patients With Metastatic Colorectal Cancer","year":2013,"lang":"en","type":"article","venue":"Clinical Pharmacology in Drug Development","topic":"Colorectal Cancer Treatments and Studies","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency; Princess Margaret Cancer Centre","funders":"Pfizer; Amgen","keywords":"Medicine; Panitumumab; Irinotecan; Pharmacokinetics; Colorectal cancer; Oncology; Pharmacology; Internal medicine; Cancer; Cetuximab","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000668861,0.0003468784,0.001281879,0.0002241362,0.0002431443,0.0004939024,0.0001971809,0.0003054407,0.0006589784],"category_scores_gemma":[0.001662908,0.0003035106,0.0003828382,0.0003775884,0.0003203524,0.0005834336,0.0001787643,0.001020719,0.0001606415],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007812492,"about_ca_system_score_gemma":0.0007704763,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006898936,"about_ca_topic_score_gemma":0.002111553,"domain_scores_codex":[0.9994403,0.000252904,0.00002866312,0.0001087113,0.0001144173,0.00005502152],"domain_scores_gemma":[0.9994504,0.0001368595,0.0001966424,0.0000348646,0.00003121489,0.0001500921],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.2912704,0.01220909,0.1425191,0.0006726598,0.002968756,0.001730853,0.0007883777,0.00798707,0.180672,0.0003118964,0.001999053,0.3568707],"study_design_scores_gemma":[0.03130577,0.4485125,0.4559142,0.00005749707,0.001801709,0.005104638,0.0002663007,0.01075224,0.03564757,0.0002532454,0.01029661,0.00008771655],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972091,0.001878974,0.0002546414,0.00006037635,0.000017881,0.00007016696,0.00005536537,0.00002020658,0.0004332603],"genre_scores_gemma":[0.9984879,0.0005631364,0.0004465548,0.00006094245,0.00003740881,0.00003661735,0.000128283,0.00000688072,0.0002322395],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001281879,"threshold_uncertainty_score":0.005668402,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0298835490165456,"score_gpt":0.3673054002709479,"score_spread":0.3374218512544023,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}